| 牛亚明,李民,徐礼笑子.MEBO与EGF在自体微粒皮种植修复肉芽创面中的临床疗效比较[J].中国烧伤创疡杂志,2012,24(1):52~54. |
| DOI：10.3969/j.issn.1001-0726.[year].[issue].[sequence] |
| 中文关键词: 肉芽创面 自体微粒皮种植 MEBO EGF |
| 英文关键词:Granulated wound Autologous micro-skin implantation MEBO Ointment EGF |
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| 中文摘要: |
| 目的 比较湿润烧伤膏（ＭＥＢＯ）、表皮细胞生长因子（ＥＧＦ）对自体微粒皮种植修复肉芽创面的临床疗效。方法 选取中老年糖尿病、瘫痪、严重全身营养不良的３８例患者，其肉芽创面面积大于５ｃｍ２，按取皮面积∶创面面积＝１∶２０～３０的比例种植自体微粒皮，将３８例患者随机分为两组，治疗组１５例（ＭＥＢＯ组），对照组２３例（ＥＧＦ组），分别用ＭＥＢＯ和ＥＧＦ换药治疗至创面愈合，观察创面皮岛修复情况及愈合时间。结果肉芽创面经自体微粒皮种植术治疗后，应用ＭＥＢＯ和ＥＧＦ治疗都能使其愈合，但治疗组（ＭＥＢＯ组） 的创面愈合率高于对照组（ＥＧＦ组）；ＭＥＢＯ组创面生长出皮岛以及愈合所需时间较ＥＧＦ组明显缩短（Ｐ＜００１）。结论肉芽创面经自体微粒皮种植术治疗后，应用ＭＥＢＯ治疗较ＥＧＦ更能有效地促进创面修复。 |
| 英文摘要: |
| Objective: To compare the clinical therapeutic efficacy between MEBO Ointment and EGF (Epidermal Growth Factor) used on granulated wounds after autologous micro-skin implantation. Methods: 38 middle- & elder-aged cases diagnosed with diabetes, paralysis and severe pantatrophia in clinics were enrolled into the study. Of those diagnosed, the size of granulated wounds was within the range of 5cm2 to 2% TBSA. The surface area ratio of implanted micro-skin to granulated wound was 1 to 20-30. 38 cases were randomly divided into a treatment group (N=15), to be given MEBO Ointment, and a control group (N=23), to be given EGF. The dressing change with MEBO Ointment and EGF respectively was performed until the closure of the granulated wound. Growth of skin islands and healing time were observed. Results: The granulated wounds, after being given autologous micro-skin implantation, could be healed by the action of MEBO Ointment or EGF. However, the healing rate in the treatment group was higher than that in the control group, and the time for the growth of skin islands and wound healing in the treatment group was apparently shorter than that in the control group (P<0.01). Conclusion: MEBO Ointment is superior to EGF in effectively promoting the healing of granulated wounds after being given autologous micro-skin implantation. |
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