| 张友群,杨柳,陶文俊,刘娟娟.重组人粒细胞巨噬细胞集落刺激因子在压疮护理中的应用[J].中国烧伤创疡杂志,2014,(2):125~129. |
| DOI： |
| 中文关键词: 压疮 护理 粒细胞巨噬细胞集落刺激因子 SD-Ag 疗效 对比 |
| 英文关键词:Pressure Ulcer Care RhGM-CSF SD-Ag Therapeutic effect Comparison |
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| 中文摘要: |
| 目的 探讨重组人粒细胞巨噬细胞集落刺激因子(rhGM?CSF) 凝胶在Ⅱ~Ⅲ度压疮创面治疗和护理中的临床应用效果? 方法 将85例(98处) Ⅱ~Ⅲ度压疮患者分为两组, 试验组创面应用重组人粒细胞巨噬细胞集落刺激因子凝胶治疗, 对照组创面应用磺胺嘧啶银(SD?Ag) 霜治疗, 观察? 对比两组患者治疗效果? 创面细菌培养及PUSH评分结果? 结果 试验组平均愈合时间为16.75d±1.22d, 有效率为96.49%, 对照组平均愈合时间为21.73d±4.55d, 有效率为78.05%? 换药14d后, 试验组患者创面PUSH评分为5.76±2.59, 对照组为8.59±3.23, 各项指标对比, 差异均具有统计学意义(P<0.01)? 结论 重组人粒细胞巨噬细胞集落刺激因子凝胶能抑制Ⅱ~Ⅲ度压疮创面细菌繁殖, 促进肉芽组织生成, 显著缩短创面愈合时间? |
| 英文摘要: |
| Objective: To investigate the clinical efficacy of Recombinant Human Granulocyte-macrophage Colony Stimulating Factor (rhGM-CSF) Gel in the wound treatment and care of II-III degree pressure ulcer. Methods: 85 patients (98 wounds) with II-III degree pressure ulcer were divided into a treatment group and a control group. The treatment group was treated with rhGM-CFS Gel and the control group was treated with SD-Ag Cream. The therapeutic effect, wound bacterial culture result and PUSH scoring were observed and compared between the two groups. Results: In the treatment group, the average healing time was 16.75 d±1.22 d and the effective rate was 96.49%. while they were 21.73 d±4.55 d and 78.05% respectively in the control group. After 14d dressing change, the PUSH scoring was 5.76±2.59 (in the treatment group) and 8.59±3.23 (in the control group) respectively. Comparison of the indicators between the two groups showed statistically significant differences (P＜0.01). Conclusion: RhGM-CSF Gel can inhibit bacteria reproduction, promote granulation tissue formation and shorten wound healing time significantly in the treatment of II-III degree pressure ulcer. |
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