| 李碧锦,杨建荣,许宇彪,何二松,林昌荣,莫凯迪,唐 毅,潘颐聪,李 军,凌凯南,刘菊珍.原位再生医疗技术对Ⅲ､Ⅳ期压疮创面面积及VEGF 表达的影响[J].中国烧伤创疡杂志,2016,(5):332~339. |
| DOI： |
| 中文关键词: 原位再生医疗技术 湿润烧伤膏 压疮 血管内皮生长因子 疗效对比 |
| 英文关键词:The in situ regenerative medical technology MEBO Pressure sores Vascular endothelial growth factor Efficacy comparison |
| 基金项目:2015 年广西医疗卫生适宜技术开发与研究项目(项目编号: S2015 57) |
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| 中文摘要: |
| 【摘要】 目的 观察原位再生医疗技术对Ⅲ?Ⅳ期压疮创面面积及血管内皮生长因子(Vascular Endothelial Growth Factor, VEGF) 表达的影响, 探讨其促进压疮创面愈合的可能机制?方法 将2015 年1 月- 2016 年3 月广西壮族自治区江滨医院收治的45 例Ⅲ?Ⅳ期压疮患者按随机数表法随机分为治疗组(24 例) 与对照组(21例), 治疗组患者创面在彻底清创后采用原位再生医疗技术治疗, 对照组患者创面在彻底清创后采用凡士林油纱换药治疗?采用免疫组织化学方法检测治疗第7 天两组患者压疮创面组织内VEGF 的表达情况; 采用透明板描绘加坐标纸法测量治疗前及治疗第30 天两组患者压疮创面面积, 对比创面面积变化情况?结果 治疗第7 天, 治疗组压疮创面组织内VEGF 的MOD 值为0?? 40 ± 0?? 12, 明显高于对照组的0?? 31 ± 0?? 11, t = 2?? 18, P < 0?? 05, 差异具有统计学意义; 治疗第30 天, 治疗组压疮创面平均面积由治疗前的(105?? 0 ± 32?? 8) cm2 缩小为(46?? 4 ±15?? 0) cm2 , 对照组压疮创面平均面积由治疗前的(101??2 ±30??4) cm2 缩小为(65??5 ±20??5) cm2, 两组对比, t =3??30,P <0??05, 差异具有统计学意义?结论 原位再生医疗技术可通过诱导VEGF 的表达促进Ⅲ?Ⅳ期压疮创面愈合? |
| 英文摘要: |
| 【Abstract】 Objective To observe the influence of the in situ regenerative medical technology on the wound size and the expression of vascular endothelial growth factor (VEGF) in pressure sores of grade Ⅲ and Ⅳ, and explore the potential mechanism of the technology in promoting the wound healing of pressure sores. Methods Forty?five patients with pressure sores of grade Ⅲ and Ⅳ admitted to Jiangbin Hospital, between January 2015 and March 2016 were divided into a treatment group (24 patients) and a control group (21 patients) according to the random number table. The treatment group was treated with the in situ regenerative medical technology following the radical debridement, while the control group was treated with the dressing change of Vaseline?impregnated gauze following the radical debridement. In the two groups, the expression of VEGF in the wounds on the day 7 of the intervention were detected by the immunohistochemical method, and the changes of wound sizes on the day 30 of the intervention were depicted with a transparent plate and measured with the coordinate paper in the two groups. Results On the day 7 of the intervention, the MOD value of VEGF in the pressure sore wounds of the treatment group was 0?? 40 ±0?? 12, which was obviously higher than that in the control group (0?? 31 ±0?? 11),t =2?? 18, P <0?? 05, showing a statistically significant difference. On the day 30 of the intervention, the mean wound size in the treatment group decreased from previous (105? . 0 ±32? . 8) cm2 to (46?? 4 ±15?? 0) cm2 while the mean wound size in the control group reduced from previous (101?? 2 ± 30?? 4) cm2 to (65?? 5 ± 20?? 5) cm2 , between which the comparison showed statistically significant difference, t =3?? 30, P <0?? 05. Conclusion The in situ regenerative medical technology can promote the wound healing of pressure sores of grade Ⅲ and Ⅳ by inducing the expression of VEGF. |
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