| 任君文,朱 旭,谢沛霖.自体富血小板血浆在慢性静脉性溃疡中的应用[J].中国烧伤创疡杂志,2017,(6):410~414. |
| DOI： |
| 中文关键词: 富血小板血浆 慢性溃疡 静脉性溃疡 疗效 |
| 英文关键词:Platelet-rich plasma Chronic ulcer Venous ulcer Efficacy |
| 基金项目: |
|
| 摘要点击次数: 2431 |
| 全文下载次数: 4733 |
| 中文摘要: |
| 目的 对比分析自体富血小板血浆(platelet-rich plasma, PRP) 治疗慢性静脉性溃疡的临床疗效?方法 将2014 年7 月—2016 年9 月武汉市第一医院周围血管科收治的64 例慢性静脉性溃疡患者随机分为PRP 组(32 例) 和对照组(32 例), 在口服地奥司明等全身综合治疗的基础上, 对照组患者创面采用藻酸盐敷料外敷治疗, PRP 组患者创面采用自体富血小板血浆联合藻酸盐敷料治疗, 治疗1 个月后对比观察两组患者的创面愈合情况?结果 治疗1 个月后, PRP 组患者治疗总有效率为84.4%, 创面面积缩小至(2.5±3.7) cm2 ; 对照组患者治疗总有效率为65.6%, 创面面积缩小至(4.2±4.0) cm2 , 两组对比, P 均<0.05, 差异具有统计学意义?治疗1 个月后, 两组患者创面愈合时间经Kaplan?Meier 生存分析显示, PRP 组患者的创面愈合时间明显短于对照组, P <0.05, 差异具有统计学意义?结论 PRP 治疗慢性静脉性溃疡, 可有效促进创面愈合, 疗效显著, 且安全性较高, 值得临床推广应用? |
| 英文摘要: |
| Objective To compare and analyze the clinical efficacy of autologous platelet-rich plasma in the treatment of chronic venous ulcer Methods 64 patients with chronic venous ulcer, admitted to Peripheral Vascular Department, Wuhan First Hospital between July 2014 and September 2016, were divided randomly into PRP group (32 cases) and control group (32 cases). In addition to systemic treatment such as oral administration of Diosmin, external application of alginate dressing was given to control group while external application of alginate dressing and autologous platelet-rich plasma treatment were given to PRP group. The wound healing condition was observed and compared after 1 month of treatment. Result After one month of treatment, the total effective rate was 84.4% and wound area was （2.5±3.7）cm2 for PRP group; the total effective rate was 65.6% and wound area was （4.2±4.0）cm2 for control group. The comparison between the two groups showed statistically significant differences(P＜0.05). Kaplan-meier method was used to compare wound healing time of the two groups and the result showed that wound healing time for PRP group was much shorter than control group. The comparison showed statistically significant difference (P＜0.05) Conclusion Platelet-rich plasma in the treatment of chronic venous ulcer can effectively promote wound healing and should be promoted in clinical practice due to its excellent efficacy and reliability. |
|
|
|
|
