| 葛 斌,舒清峰,唐乾利.免疫反应在创面修复中的作用研究进展[J].中国烧伤创疡杂志,2018,(3):153~156. |
| DOI： |
| 中文关键词: 免疫反应 创面 修复 炎症反应 综述 |
| 英文关键词:Immune response Wound Repair Inflammatory response Review |
| 基金项目:国家自然科学基金(81560776) |
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| 中文摘要: |
| 【摘要】 免疫反应在创面修复中具有双重作用, 既可促进创面的再生修复, 又会延迟创面的愈合。如创面修复的炎症反应期可见大量中性粒细胞、巨噬细胞、T淋巴细胞等聚集于创面, 参与并启动机体局部和全身的免疫防御, 诱导产生大量细胞生长因子, 促进创面的再生愈合; 创面持续的免疫反应又可诱发局部组织损伤, 导致创面延迟愈合。遂本文对免疫反应在创面修复领域的研究进展进行了综述, 旨在为创面修复的临床和基础研究提供思路与线索。 |
| 英文摘要: |
| 【Abstract】 Objective Immune response, playing a dual role in wound repair, on the one hand, can promote the regenerative repair of wound and on the other hand, delay the wound healing. For instance, at the inflammatory stage of wound repair, a large number of cells such as neutrophile granulocyte, macrophagocyte and T cells aggregate on wound surface to participate in and initiate the systemic and local immune defenses, which induces the production of a plenty of cell growth factors to promote the wound regenerative healing. At the meantime, the sustained immune responses can result in local tissue damage, leading to delayed wound healing. Thus, this paper reviewed the research progress in immune responses in relation to wound repair, with the aim of providing insights and clues for the clinical and scientific research on wound repair. |
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