| 朱 周,顾丽群,任 祺,花 卉,汪 笑.痤疮合剂联合ALA-PDT治疗中重度寻常性痤疮疗效观察[J].中国烧伤创疡杂志,2018,(3):205~209. |
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| 中文关键词: 寻常性痤疮 痤疮合剂 5-氨基酮戊酸光动力疗法 盐酸米诺环素胶囊 疗效 |
| 英文关键词:Moderate and severe acne vulgaris Acne mixture 5-aminolevulinic Photodynamic Therapy(ALA-PDT) Minocycline hydrochloride capsule Curative effect |
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| 中文摘要: |
| 【摘要】 目的 观察痤疮合剂联合5-氨基酮戊酸光动力疗法(ALA-PDT)治疗中重度寻常性痤疮的临床疗效和安全性。方法 采用随机数表法将2016年8月—2017年12月南通市第三人民医院皮肤科收治的96例中重度寻常性痤疮患者随机分为试验组(46例) 与对照组(50例), 其中试验组患者采用痤疮合剂联合ALA-PDT治疗, 对照组患者采用盐酸米诺环素胶囊治疗, 对比观察两组患者的皮损创面愈合情况、不良反应发生情况及复发情况等。结果 治疗过程中, 试验组患者中有8例患者发生局部不良反应, 对照组患者中有5例患者发生局部不良反应, 两组对比采用四格表资料的卡方检验, χ2=1.118, P=0.290, P>0.05, 差异无统计学意义; 治疗后两组患者皮损创面均逐渐好转, 创面评分均逐渐降低, 其中治疗2、4、6周后两组患者皮损创面评分对比采用t检验, t值分别为7.301、7. 050及4.949, P均<0.01, 差异具有统计学意义; 治疗6周后, 两组患者临床疗效对比采用等级资料的秩和检验, mann-whitney U=807.000, Z=2.648, P=0.008, P<0.01, 差异具有统计学意义;3个月后随访, 试验组患者中有1例患者复发, 对照组患者中有8例患者复发, 两组对比采用四格表资料的卡方检验, χ2=3.886, P=0.021, P<0.05, 差异具有统计学意义。结论 痤疮合剂联合ALA-PDT治疗中重度寻常性痤疮, 可有效促进皮损创面痊愈, 降低复发率, 疗效显著, 值得临床推广应用。 |
| 英文摘要: |
| 【Abstract】 Objective To observe the curative effect of acne mixture in combination with 5-aminolevulinic Photodynamic Therapy (ALA-PDT) in treating moderate and severe acne vulgaris. Methods Ninety-six patients with moderate and severe acne vulgaris admitted to the Dermatology Department of Nantong Third People’s Hospital between August 2016 and December 2017 were randomly divided into an experiment group (46 cases) and a control group (50 cases) according to the random number table, of which patients in the experiment group were treated with acne mixture in combination with ALA-PDT while patients in the control group were treated with Minocycline hydrochloride capsule. The healing condition of skin lesion, incidence of adverse reactions and relapse of acne vulgaris were observed and compared between the two groups.Results During the treatment, the experiment group observed local adverse reactions in 8 cases while there were 5 cases suffered from adverse reactions in the control group, which showed no statistically significant difference according to the Chisquare test of fourfold table, χ2=1.118, P=0.290, P>0.05. After the treatment, skin lesions in the two groups all gradually turned better, with a gradually decreased trend of wound score. t test was used for the comparison of scores of skin lesion wounds at respective two weeks, four weeks and six weeks after the treatment in the two groups and the results showed statistically significant difference, t=7.301, 7.050 and 4.949 respectively, all P<0.01. Six weeks after the treatment,the curative effects in the two groups were compared with the rank-sum test of ranked data, which showed statistically significant difference (mann-whitney U=807.000, Z=2.648, P=0.008, P<0.01). During the follow-up of three months,one case in the experiment group developed the acne again while there were eight relapsed cases in the control group, which has a statistically significant difference based on the Chi-square test of fourfold table, χ2=3.886, P=0.021, P<0.05.Conclusion In the treatment of moderate and severe acne vulgaris, acne mixture in combination with ALA-PDT can effectively promote the healing of skin lesions and decrease relapse rate, deserving to be promoted in clinical practice. |
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