| 黄 英,曾良玉,贺许良.湿润烧伤膏联合银离子抗菌敷料对感染性压疮患者血清炎症因子的影响及临床疗效观察[J].中国烧伤创疡杂志,2019,(1):14~18. |
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| 中文关键词: 湿润烧伤膏 银离子抗菌敷料 压疮 炎症因子 影响 疗效 |
| 英文关键词:MEBO Silver ion antibacterial dressing Pressure ulcer Inflammatory factor Influence Clinical effect |
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| 中文摘要: |
| 【摘要】 目的 探讨湿润烧伤膏联合银离子抗菌敷料对感染性压疮患者血清炎症因子的影响及临床疗效?方法 采用随机数表法将2014 年7 月至2018 年5 月株洲市人民医院收治的60 例感染性Ⅲ期压疮患者随机分为试验组(30 例) 与对照组(30 例), 其中试验组患者创面采用湿润烧伤膏联合银离子抗菌敷料治疗, 对照组患者创面单纯采用湿润烧伤膏治疗, 对比观察两组患者的血清炎症因子变化情况及临床疗效?结果 治疗后两组患者血清白细胞介素-6 (interleukin 6, IL-6)?白细胞介素?8 (interleukin 8, IL-8)?肿瘤坏死因子-α (tumor necrosis factor α, TNF-α) 及超敏C 反应蛋白(hypersensitive C-reactive protein, hs-CRP) 表达水平均逐渐降低, 且尤以试验组降低最为明显, 治疗后7?14 d, 两组患者血清IL-6?IL-8?TNF-α 及hs-CRP 表达水平对比, P 均< 0.01,差异具有统计学意义; 治疗6 周后, 试验组患者中痊愈19 例?有效9 例?无效2 例?总有效率为93.33%, 对照组患者中痊愈15 例?有效7 例?无效8 例?总有效率为73.33%, 两组对比, P > 0.05, 差异无统计学意义?结论 湿润烧伤膏联合银离子抗菌敷料治疗感染性压疮, 可有效抑制炎症因子的释放, 减轻压疮创面的炎症反应程度? |
| 英文摘要: |
| 【Abstract】 Objective To investigate the influence of MEBO combined with silver ion antibacterial dressing on serum inflammatory factors in patients with infectious pressure ulcer and its clinical effect. Methods Sixty patients with stage III pressure ulcers, admitted into Zhuzhou People’s Hospital from July 2014 to May 2018, were randomly divided into an experiment group (30 cases) and a control group (30 cases) according to the random number table. Patients in the experiment group were treated with MEBO combined with silver ion antibacterial dressing whereas patients in the control group were treated simply with MEBO. Changes of serum inflammatory factors and the clinical effects were compared and observed in the two groups. Results After treatment in the two groups, the expression levels of serum interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and C-reactive protein (hs-CRP) all gradually decreased, especially in the experiment group. On respective day 7 and 14 after treatment, the expression levels of serum IL-6, IL-8, TNF-α and hs-CRP were compared between the two groups and the results showed statistically significant differences (all P < 0.01). After 6 weeks of treatment, 19 patients were cured, 9 cases showed effective treatment, 2 were ineffective, and the total effective rate was 93.33% in the treatment group, while in the control group, 15 were cured, 7 showed effective treatment, 8 ineffective, and the total effective rate was 73.33%, based on which no statistically significant difference was observed (all P > 0.05). Conclusion MEBO combined with silver ion antibacterial dressing in the treatment of infectious pressure ulcer can effectively inhibit the release of inflammatory factors and reduce the inflammatory reaction in pressure ulcer wounds. |
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