| 贺许良,曾良玉,黄 英,易小龙,张树友.生长抑素联合乌司他丁对术后早期炎性肠梗阻患者血清炎症细胞因子的影响[J].中国烧伤创疡杂志,2019,(5):376~380. |
| DOI： |
| 中文关键词: 生长抑素 乌司他丁 炎性肠梗阻 细胞因子 影响 |
| 英文关键词:Growth inhibitors Urinastatin Inflammatory small bowel obstruction Cytokines Effect |
| 基金项目:2016 年湖南省株洲市科技计划基金项目 (2016-13) |
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| 中文摘要: |
| 【摘要】 目的 探讨生长抑素联合乌司他丁对术后早期炎性肠梗阻患者血清炎症细胞因子的影响? 方法 选取 2015 年 5 月至 2017 年 10 月长沙医学院附属株洲市人民医院收治的 50 例术后早期炎性肠梗阻患者作为研究对象，并按照随机数表法将其随机分为试验组 (25 例) 与对照组 (25 例)，其中试验组患者在胃肠减压、抗感 染、纠正水电解质紊乱等治疗的同时予以生长抑素联合乌司他丁治疗，对照组患者在胃肠减压、抗感染、纠正水 电解质紊乱等治疗的同时予以生长抑素治疗，对比观察两组患者治疗前 1 d 及治疗第 3、7 天白细胞介素-6 (IL-6)、白细胞介素-8 (IL-8)、肿瘤坏死因子-α (TNF-α) 及超敏 C-反应蛋白 ( hs-CRP) 等血清炎症细胞因子的变化情况? 结果 除治疗第 3 天，对照组患者 hs-CRP水平与治疗前对比无明显变化，P>0.05，差异无统计学意义外，其他各时间点两组患者血清 IL-6、IL-8、TNF-α及 hs-CRP 水平组内两两对比，P 均<0.05，差异具有统 计学意义；治疗第 3、7 天两组患者血清 IL-6、IL-8、TNF-α 及 hs-CRP 水平组间对比，P 均<0.05，差异具有统计学意义；治疗第 7 天，试验组患者的治疗总有效率为 88.0%，对照组患者的治疗总有效率为 68.0%，两组对 比，P<0.05，差异具有统计学意义；治疗过程中，试验组患者不良反应发生率为 8.0%，对照组患者不良反应发生率为 32.0%，两组对比，P<0.05，差异具有统计学意义? 结论 生长抑素联合乌司他丁可减轻术后早期炎性肠梗阻患者的炎症反应，降低不良反应发生率，提高治疗效果? |
| 英文摘要: |
| 【Abstract】 Objective To investigate the effect of growth inhibitors combined with Urinastatin on the serum in- flammatory cytokines in patients with early postoperative inflammatory small bowel obstruction (EPISBO). Methods Fifty patients with EPISBO admitted into Zhuzhou People’s Hospital Affiliated to Changsha Medical University between May 2015 and October 2017 were selected as subjects to be divided into an experiment group (25 cases) and a control group (25 ca- ses) according to the random number table. Besides the treatments of decompressing the gastrointestine，fighting infection and correcting the disturbance of water and electrolyte，the patients in the experiment group were treated with growth inhibi- tors combined with Urinastatin while the patients in the control group were treated simply with growth inhibitors. The chan- ges of serum inflammatory cytokines including interleukin-6 (IL-6)，interleukin-8 (IL-8)，tumor necrosis factor-α (TNF-α) and hypersensitivity C-reactive protein (hs-CRP) were observed and compared between the two groups respective- ly on one day before the treatment and on day 3 and 7 of the treatment. Results On day 3 of the treatment in the control group，the expression levels of hs-CRP showed no statistically significant difference as compared with that before the treat- ment，P>0.05. However，the pairwise comparison of the expression levels of serum IL-6，IL-8，TNF-α and hs-CRP at the other two time points within each of the two groups all showed statistically significant differences，all P<0.05. On day 3 and 7 of the treatment，the expression levels of serum IL-6，IL-8，TNF-α and hs-CRP were respectively compared between the two groups，and the results showed statistically significant differences，all P<0.05. On day 7 of the treatment，the total effective rate in the experiment group was 88.0%，which presented a statistically significant difference as compared with the corresponding 68.0% in the control group，P<0.05. During the course of treatment，the incidence of adverse reaction in the experiment group was 8.0% while that in the control group was 32.0%，between which the difference was statistically significant，P<0.05. Conclusion Growth inhibitors in combination with Urinastatin can alleviate the inflammatory reac- tion of patients with EPISBO，decrease the incidence of adverse reactions and improve the therapeutic effect. |
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