| 王 楠.两种皮肤防护剂防治头颈部恶性肿瘤患者放射性皮肤损伤疗效对比[J].中国烧伤创疡杂志,2019,31(6):391~393. |
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| 中文关键词: 头颈部恶性肿瘤 利肤宁 三乙醇胺乳膏 放射性皮肤损伤 疗效 |
| 英文关键词:Head and neck malignancies Lifuning Triethanolamine Cream Radiation-induced skin injury Therapeutic effect |
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| 中文摘要: |
| 【摘要】 目的 对比观察两种皮肤防护剂对头颈部恶性肿瘤患者放射性皮肤损伤的防治效果?方法 回顾性分析2016 年8 月至2018 年8 月大连市中心医院放疗科收治的57 例采用放射治疗皮肤防护剂(利肤宁, 设为试验组) 与53 例采用三乙醇胺乳膏(设为对照组) 预防放射性皮肤损伤的行放射治疗的头颈部恶性肿瘤患者的病历资料, 两组患者除外用药不同外, 其他治疗方法均相同, 对比两组患者放射治疗期间放射性皮肤损伤程度及不同放射剂量时放射性皮肤损伤发生情况?结果 (1) 放射治疗1 周后, 试验组患者中皮肤出现1 级损伤者18例?2 级损伤者37 例?3 级损伤者2 例, 对照组患者中皮肤出现1 级损伤者10 例?2 级损伤者29 例?3 级损伤者13 例?4 级损伤者1 例, 两组对比, P <0.05, 差异具有统计学意义?(2) 试验组患者在放射剂量为20 Gy 以下时均未出现皮肤损伤; 在放射剂量为20～40 Gy 时, 有18 例患者出现皮肤损伤; 在放射剂量为40 Gy 以上时, 有39 例患者出现皮肤损伤?对照组患者在放射剂量为20 Gy 以下时, 有1 例患者出现皮肤损伤; 在放射剂量为20～40 Gy时, 有29 例患者出现皮肤损伤; 在放射剂量为40 Gy 以上时, 有23 例患者出现皮肤损伤?两组患者接受不同放射剂量时皮肤损伤发生情况对比, P <0.05, 差异具有统计学意义?结论 利肤宁可有效延长头颈部恶性肿瘤患者放射治疗期间放射性皮肤损伤的发生时间, 降低皮肤损伤程度, 疗效显著, 临床应用价值较高? |
| 英文摘要: |
| 【Abstract】 Objective To explore the effects of two skin protectants in preventing and treating the radiation-induced skin injury in patients with head and neck malignancies. Methods The medical records of 57 patients that used a skin protectant-Lifuning (experiment group) and 53 patients that used Triethanolamine Cream (control group) to prevent radiation-induced skin injury during the radiotherapy in the Department of Radiotherapy of Dalian Municipal Central Hospital between August 2016 and August 2018 were retrospectively analyzed. In the two groups, except the two different skin protectants,all the other treatments were same. The degree of radiation-induced skin injury and the occurrence of radiation-induced skin injury under different radiation doses during the radiotherapy were compared between the two groups. Results (1) After one week of radiotherapy, in the experiment group, 18 patients developed grade Ⅰ skin injury, 37 patients developed grade Ⅱ skin injury and 2 patients developed grade Ⅲ skin injury, while in the control group, 10 patients developed grade Ⅰ skin injury, 29 patients developed grade Ⅱ skin injury, 13 patients developed grade Ⅲ skin injury and 1 patient developed grade Ⅳ skin injury, between which the difference was statistically significant (P <0.05). (2) In the experiment group, no patient developed skin injury when the radiation dose was under 20 Gy, while when the radiation dose was 20 -40 Gy,18 patients developed skin injury, and when the radiation dose was above 40 Gy, skin injury appeared in 39 patients. In contrast, in the control group one patient developed skin injury under the radiation dose of less than 20 Gy, 29 patients developed skin injury when the radiation dose was 20 - 40 Gy and 23 patients developed skin injury when the radiation dose was above 40 Gy. The comparison between the two groups in terms of the occurrence of skin injury under different radiation doses showed a statistically significant difference, P <0.05. Conclusion The skin protectant Lifuning can effectively delay the appearance of radiation-induced skin injury in patients with head and neck malignancies during the radiotherapy, and decrease the degree of skin injury, presenting a higher clinical application value. |
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