董 毅,马秀峰,曹建红,买喜丽,张 玲.重度烧伤合并脓毒症相关性脑病患者血清IL-6与TNF-α的表达水平及临床意义[J].中国烧伤创疡杂志,2020,(1):26~28. |
DOI: |
中文关键词: 重度烧伤 脓毒症 脓毒症相关性脑病 白细胞介素-6 肿瘤坏死因子-α 临床意义 |
英文关键词:Severe burns Sepsis Sepsis-related encephalopathy Interleukin-6 Tumor necrosis factor-α Clinical significance |
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中文摘要: |
【摘要】 目的 研究重度烧伤合并脓毒症相关性脑病患者血清白细胞介素-6 ( IL-6) 及肿瘤坏死因子-α (TNF-α) 的水平变化,分析其临床意义? 方法 回顾性分析 2017 年 7 月至 2019 年 6 月中国人民解放军联勤保障 部队第九八八医院收治的采用相同创面治疗方法治疗的 92 例重度烧伤合并脓毒症患者的临床资料,将 26 例合并 脓毒症相关性脑病的患者设为脑病发生组,将 66 例未发生脓毒症相关性脑病的患者设为脑病未发组,对比观察 两组患者入院时及治疗第 7、14、21 天时血清 IL-6、TNF-α水平? 结果 治疗第 7、14、21 天,两组患者血清 IL-6、TNF-α 水平均呈先升高后降低的趋势 (脑病发生组: F=133.400、53.410,P=0.000、0.000;脑病未发 组: F=92.980、56.430,P=0.000、0.000),且各时间点脑病发生组患者血清 IL-6、TNF-α 水平均明显高于脑 病未发组 (IL-6: t=8.006、8.345、5.347,P=0.000、0.000、0.000;TNF-α: t=3.525、7.960、3.354,P=0.001、0.000、0.001)? 结论 重度烧伤合并脓毒症相关性脑病患者的血清 IL-6、TNF-α 水平显著升高,动态监 测这两项指标的变化情况可作为早期诊断及预防脓毒症相关性脑病的主要手段? |
英文摘要: |
【Abstract】 Objective To study the changes of levels of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in patients with severe burn complicated with sepsis-related encephalopathy and analyze their clinical significance. Methods Clinical data of 92 patients with severe burn complicated with sepsis-related encephalopathy treated with the same wound therapy in 988RD Hospital of PLA from July 2017 to June 2019 were retrospectively analyzed. 26 patients with sepsis-related encephalopathy were assigned to the encephalopathy group and 66 patients without sepsis-related encephalopathy were assigned to the non-encephalopathy group. The levels of IL-6,TNF-α were analyzed and compared between the two groups on admission and on day 7,14,21 of treatment. Results On day 7,14 and 21 of treatment,the levels of serum IL-6 and TNF-α of patients in the two groups increased first and then decreased ( encephalopathy group: F=133.400,53.410,P=0.000,0.000;non-encephalopathy group: F=92.980,56.430,P=0.000,0.000) and the levels of serum IL-6 and TNF-α in the encephalopathy group at each time point were significantly higher than those in the non- encephalopathy group (IL-6: t=8.006,8.345,5.347,P=0.000,0.000,0.000;TNF-α: t=3.525,7.960,3.354,P=0.001,0.000,0.001). Conclusion The levels of serum IL-6 and TNF-α in patients with severe burn complicated with sepsis-related encephalopathy increased notably. Dynamic monitoring of the changes of these two indicators are important means to diagnose and prevent sepsis-related encephalopathy. |
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