| 【Abstract】 Objective To study the effect of continuous ultrasound-guided paravertebral nerve block on the pain and stress response of patients undergoing radical mastectomy. Methods 70 female patients who underwent radical mastectomy in Cangzhou Central Hospital from July 2018 to June 2019 were selected as study subjects and divided, according to random number table, into an observation group (35 cases) and a control group (35 cases). Patients in the observation group were anesthetized and given analgesia with continuous ultrasound-guided paravertebral nerve block, while patients in the control group were given routine general anesthesia and then intravenous analgesia. Pain degree and changes of interleukin-6 (IL-6), tumor necrosis factor – α (TNF-α), hypersensitive c-reactive protein (hs-CRP) were compared between the two groups. Results After the surgery, the pain scores of the two groups gradually decreased (F = 836.000, 870.000, all P = 0.000) and the pain scores in the observation group were significantly lower than those in the control group at 6, 12, 24, and 48 h after the surgery (t = 2.254, 35.144, 8.588, 2.597, P = 0.027, 0.000, 0.000, 0.012); after the surgery, the levels of IL-6, TNF-α, and hs-CRP in the two groups showed a trend of increase first followed by decrease, and their levels in the observation group were significantly lower than those in the control group at each time point (12 hours after the surgery: t = 4.292, 8.156, 4.933, all P = 0.000; 24 hours after the surgery: t = 5.868, 4.500, 2.666, P = 0.000, 0.000, 0.010). Conclusion Ultrasound-guided continuous paravertebral nerve block can significantly reduce the pain degree and the stress response level in patients undergoing radical mastectomy, it deserves further research. |
