| 【Abstract】 Objective To compare the effect of minimally invasive laparoscopic surgery and laparotomy on the immune function and stress response of patients with colorectal cancer and the therapeutic efficacy. Methods Forty-three patients with colorectal cancer, admitted to the General Surgery of Zhoukou Hospital of Traditional Chinese Medicine from May 2015 to May 2019, were selected as study subjects, and then divided, according to random number table, into a study group (22 cases) and a control group (21 cases). Patients in the study group were treated with minimally invasive laparoscopic surgery while patients in the control group were treated with laparotomy. The clinical efficacy, the levels of immune-related indicators such as CD3 +, CD4 +, CD8 +, the levels of inflammatory factors such as interleukin-6 (IL-6), c-reactive protein (CRP) and tumor necrosis factor - (TNF-) and karnofsky performance status (KPS) of patients in the two groups were compared before and after surgery. Results The surgery time in the study group was significantly longer than that in the control group (t’ = 4.431, P = 0.000)；the intraoperative blood loss in the study group was significantly less than that in the control group (t’ = 10.323, P = 0.000); the intestinal peristalsis recovery time and duration of hospitalization in the study group were significantly shorter than those in the control group (t / t '= 7.129, 6.220, P = 0.000, 0.000); 3 and 7 days after the surgery, the levels of CD3 + and CD4 + in the two groups showed a trend of decrease first followed by increase；their levels in the study group was significantly higher than those in the control group and the comparison showed statistically significant difference (3 d: t / t '= 2.251, 4.795, P = 0.031, 0.000; 7 d: t = 2.353, 3.100, P = 0.023, 0.003); the level of CD8 + showed a trend of increase first followed by decrease. Its level in the study group was significantly lower than that in the control group and the comparison showed statistically significant difference (3 d: t = 2.415, P = 0.020; 7 d: t = 2.714, P = 0.010 ); 3 and 7 days after the surgery, the levels of IL-6, CRP and TNF-α in the two groups showed a trend of increase first followed by decrease: the levels of IL-6, CRP and TNF-α in the study group were significantly lower than those in the control group and the comparison showed statistically significant difference (3 d: t / t '= 3.430, 2.188, 3.670, P = 0.002, 0.034, 0.001; 7 d: t / t' = 2.529, 2.971, 2.127, P = 0.016 0.006,0.041); 2 weeks after the surgery, KPS score in the study group was significantly higher than that in the control group and the comparison showed statistically significant difference (t = 3.361, P = 0.002). Conclusion Minimally invasive laparoscopic surgery for colorectal cancer can shorten patients’ postoperative recovery time, reduce their systemic stress response, improve their immune function and quality of life, so it has good curative effect and high value of clinical application. |
