| 王中良,许贺春,白 洁.消化内镜联合四联疗法对胃溃疡伴活动性出血的疗效观察及再出血原[J].中国烧伤创疡杂志,2020,(3):214~217. |
| DOI： |
| 中文关键词: 消化内镜 四联疗法 胃溃疡 活动性出血 再出血 危险因素 |
| 英文关键词:Digestive endoscopy Quadruple therapy Gastric ulcer Active bleeding Rebleeding Risk factors |
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| 中文摘要: |
| 目的 观察消化内镜联合四联疗法对胃溃疡伴活动性出血的治疗效果，并分析其再出血的相关危险因素。方法 选取2016年9月至2018年9月焦作煤业集团有限责任公司中央医院消化科收治的88例胃溃疡伴活动性出血患者作为研究对象，并按照入院顺序单双号将其分为观察组与对照组，每组44例，观察组患者采用消化内镜联合四联疗法治疗，对照组患者单纯采用四联疗法治疗，对比两组患者的临床疗效，观察两组患者治疗后再出血的发生情况，并分析再出血的相关危险因素。结果 治疗2周后，观察组患者临床疗效明显优于对照组（Mann-Whitney U=708.500，Z=-2.380，P=0.017）；经多因素Logistic回归分析发现，血红蛋白含量低、溃疡为A1期及未联合消化内镜治疗是患者再出血的独立危险因素（OR=1.792、1.165、1.879，P=0.015、0.022、0.031）。结论 胃溃疡伴活动性出血患者应用消化内镜联合四联疗法治疗，可有效提高治疗效果，降低再出血发生率，且患者血红蛋白含量低及溃疡为A1期也是胃溃疡伴活动性出血患者再出血的独立危险因素，应加以重视。 |
| 英文摘要: |
| 【Abstract】 To observe the curative effect of digestive endoscopy combined with quadruple therapy in the treatment of gastric ulcer with active bleeding and analyze the related risk factors for ulcer rebleeding. Methods 88 patients suffering from gastric ulcers combined with active bleeding, admitted to Department of Gastroenterology, the Central Hospital of Jiaozuo Coal Industry Group Co., Ltd. from September 2016 to September 2018, were selected as research subjects, and then divided, according to the odevity of their admission number, into an observation group (44 cases) and a control group (44 cases). Patients in the observation group were treated with digestive endoscopy combined with quadruple therapy, while patients in the control group were treated with quadruple therapy only. The curative effect was compared between the two groups, the occurrence of rebleeding after treatment in the two groups was observed, and the related risk factors for ulcer rebleeding were analyzed. Results After 2 weeks of treatment, the curative effect of the observation group was significantly better than the control group (Mann-Whitney U = 708.500, Z = -2.380, P = 0.017); it was found with multivariate logistic regression analysis that independent risk factors for ulcer rebleeding were: low hemoglobin content, ulcer at A1 stage, and no combination of digestive endoscopy in the treatment (OR = 1.792, 1.165, 1.879, P = 0.015, 0.022, 0.031). Conclusion Use of Digestive endoscopy combined with quadruple therapy in patients with gastric ulcers and active bleeding can improve therapeutic effect and reduce the incidence of rebleeding. Moreover, the low hemoglobin content and ulcer being at A1 stage are also independent risk factors for ulcer rebleeding, which should be taken seriously |
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