| 孟 真,高 楠,石 倩,王万海.外周血中性粒细胞 CD64 及 CRP 在烧伤感染中的诊断价值探讨[J].中国烧伤创疡杂志,2020,(4):254~257. |
| DOI： |
| 中文关键词: 外周血 中性粒细胞CD64 C反应蛋白 烧伤 感染 脓毒症 |
| 英文关键词:Peripheral blood Neutrophil CD64 C⁃reactive protein Burns Infection Sepsis |
| 基金项目: |
|
| 摘要点击次数: 1871 |
| 全文下载次数: 4178 |
| 中文摘要: |
| 目的 分析探讨外周血中性粒细胞CD64及C反应蛋白(CRP)在烧伤感染中的诊断价值? 方法 选择 2018 年 1 月至 2019 年 6 月郑州大学第一附属医院烧伤科收治的 92例烧伤患者作为研究对象, 并按照感染程度将其分为脓毒症组 (31例)? 局部感染组 (21例) 和非感染组 (40例), 分别于治疗前和治疗第3? 7 天测定并对比外周血中性粒细胞CD64及CRP水平, 绘制中性粒细胞 CD64? CRP及两项指标联合检测对烧伤感染诊断价值 ROC曲线, 分析其特异度和敏感度? 结果 治疗前3组患者中性粒细胞 CD64 及 CRP水平对比, 脓毒症组明显高于局部感染组与非感染组 (P均 < 0.05), 局部感染组明显高于非感染组 (P < 0.05); 治疗第 3? 7 天 3 组患者中性粒细胞 CD64及CRP水平均呈现不同程度下降, 但脓毒症组仍明显高于局部感染组与非感染组 (P均<0.05), 局部感染组仍明显高于非感染组 (P < 0.05)? ROC 曲线分析结果显示: 中性粒细胞 CD64? CRP 及两项指标联合检测的曲线下面积分别为0.719? 0.655 及0.872; 两项指标联合检测的敏感度? 特异度分别为 88.46%? 87.50%, 明显高于中性粒细胞CD64的敏感度80.77%? 特异度77.50%及CRP的敏感度 71.15%? 特异度67.50%? 结论 外周血中性粒细胞CD64 及 CRP水平与烧伤患者感染程度密切相关, 在烧伤感染的早期诊断中具有一定价值, 且两项指标联合检测的诊断价值更高。 |
| 英文摘要: |
| Objective To analyze the diagnostic value of peripheral blood neutrophil CD64 and C-reactive protein (CRP) in burn infection. Methods 92 burn patients, admitted to the Department of Burns of the First Affiliated Hospital of Zhengzhou University from January 2018 to June 2019, were selected as research subjects and divided, according to the degree of infection, into sepsis group (31 cases), local infection group (21 cases) and non?infection group (40 cases). The levels of peripheral blood neutrophil CD64 and CRP were measured and compared before treatment and on the 3rd and 7th day of treatment, respectively. The ROC curves for predicting burn infection with neutrophils CD64, CRP and the combination of the two indicators were drawn, and their specificity and sensitivity were analyzed. Results The levels of neutrophil CD64 and CRP in the three groups were compared before treatment: their levels in the sepsis group were significantly higher than that in the local infection group and the non-infection group (all P < 0.05), and their levels in the local infection group was significantly higher than that in the non?infection group (P < 0.05); on day 3 and day 7 of treatment, the levels of neutrophil CD64 and CRP in the three groups showed different degrees of decrease: their levels in the sepsis group was still significantly higher than that in the local infection group and the non?infection group (all P < 0.05), and their levels in the local infection group was still significantly higher than that in the non-infected group (P < 0.05). ROC curve analysis showed that the areas under the curves of neutrophil CD64, CRP and the combination of the two indicators were 0.719, 0.655 and 0.872, respectively; the sensitivity and specificity of the detection with the combination of the two indicators were 88.46% and 87.50% , significantly higher than the sensitivity and specificity of neutrophil CD64-80.77% and 77.50% , and sensitivity and specificity of CRP-71.15% and 67.50% . Conclusion The levels of neutrophil CD64 and CRP are closely related to the degree of infection of burn patients. They have certain value in the early diagnosis of burn infection, and the detection with the combination of the two indicators has even higher diagnostic value. |
|
|
|
|
