| 崔泽龙,张雪梅.A型肉毒毒素在瘢痕治疗中的研究进展[J].中国烧伤创疡杂志,2020,(4):295~297. |
| DOI： |
| 中文关键词: A型肉毒毒素 增生性瘢痕 瘢痕疙瘩 成纤维细胞 胶原纤维 研究进展 |
| 英文关键词:Botulinum Toxin Type A Hypertrophic scar Keloid Fibroblast Collagen fiber Research progress |
| 基金项目: |
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| 摘要点击次数: 1743 |
| 全文下载次数: 4799 |
| 中文摘要: |
| A型肉毒毒素是由肉毒杆菌分泌的高分子蛋白神经毒素，可通过抑制乙酰胆碱释放而松弛肌肉，常被用于解除肌肉痉挛、除皱美容等神经疾病治疗及皮肤美容领域。近年来研究证实，A型肉毒毒素能够通过抑制瘢痕组织内成纤维细胞增殖、促进瘢痕组织内胶原纤维降解、降低转化生长因子β活性及创面周围组织张力达到促进瘢痕消退、减轻瘢痕瘙痒及疼痛、降低瘢痕复发等目的，被广泛应用于增生性瘢痕和瘢痕疙瘩的治疗。鉴于此，本研究对A型肉毒毒素治疗瘢痕的研究进展进行了综述，以期为A型肉毒毒素的临床治疗提供帮助。 |
| 英文摘要: |
| Botulinum toxin type A is a neurotoxic protein with high molecular weight produced by the bacterium Clostridium botulinum. It can relax muscles by inhibiting the release of acetyl choline, and is often used for the treatment of nerve diseases to relieve muscle spasm and for cosmetic purposes such as wrinkle smoothing. In recent years, some studies have confirmed that botulinum toxin type A can realize the effects of promoting scar disappearance, relieving scar itching and pain, and reducing relapse of scar by inhibiting the proliferation of fibroblasts in scar tissues, promoting the degradation of collagen fibers in scar tissues, and decreasing the activity of transforming growth factor β and tissue tension in wound periph? ery, and thus it has been widely applied in the treatment of hypertrophic scar and keloid. In view of this, this study made a review on the research progress of botulinum toxin type A in treating scar, with the purpose of providing reference for the clinical application of botulinum toxin type A. |
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