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连续性血液净化在重度烧伤脓毒症患者中的应用效果分析
Analysis on the Application Effect of Continuous Blood Purification in the Treatment of Severe Burn Patients with Sepsis

王星利.连续性血液净化在重度烧伤脓毒症患者中的应用效果分析[J].中国烧伤创疡杂志,2020,(6):403~405.

DOI：

英文关键词:Severe burn Sepsis Continuous blood purification Curative effect

基金项目:

作者	单位
王星利	平煤神马医疗集团总医院

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中文摘要:

【摘要】目的对比分析连续性血液净化在重度烧伤脓毒症患者中的应用效果。方法选取2016年1月至2019年10月平煤神马医疗集团总医院收治的50例重度烧伤脓毒症患者作为研究对象，并按照不同治疗方法将其分为试验组（25例）与对照组（25例），对照组患者予以营养支持、抗休克、抗感染等对症支持治疗，试验组患者在常规治疗的基础上行连续性血液净化治疗，对比两组患者动脉血氧分压、白细胞计数、血肌酐、血尿素氮、肿瘤坏死因子-α（TNF-α）及白细胞介素-8（IL-8）水平。结果治疗后，试验组患者动脉血氧分压明显高于对照组（t=5.402，P=0.000），白细胞计数、血肌酐、血尿素氮、TNF-α及IL-8水平明显低于对照组（t=3.343、2.346、4.339、11.180、6.934，P=0.002、0.023、0.000、0.000、0.000）。结论重度烧伤脓毒症患者应用连续性血液净化治疗，可有效降低机体炎症反应程度，改善各器官功能，效果显著。

英文摘要:

【Abstract】Objective To compare and analyze the application effect of continuous blood purification in the treatment of severe burn patients with sepsis. Methods Fifty severe burn patients complicated with sepsis, admitted to the General Hospital of Pingmei Shenma Medical Group from January 2016 to October 2019, were selected as research subjects to be divided, according to their different treatment methods, into an experiment group (25 cases) and a control group (25 cases). Patients in the control group were given such symptomatic supportive treatments as nutritional support, anti-shock and anti-infection, etc., while in the experiment group, besides the above mentioned conventional treatments, patients also received continuous blood purification. The arterial partial pressure of oxygen, white blood cell count, serum creatinine, blood urea nitrogen, tumor necrosis factor-α (TNF-α) level and interleukin-8 (IL-8) level were compared between the two groups. Results After treatment, the arterial partial pressure of oxygen in the experiment group was significantly higher than that in the control group (t=5.402, P=0.000), and the white blood cell count, blood creatinine, blood urea nitrogen, TNF-α level and IL-8 level in the experiment group were significantly lower than that in the control group (t=3.343, 2.346, 4.339, 11.180 and 6.934 respectively, P=0.002, 0.023, 0.000, 0.000 and 0.000 respectively). Conclusion Continuous blood purification in treating severe burn patients complicated with sepsis can effectively decrease the inflammatory responses and improve the functions of organs of patients, presenting significant therapeutic effect.