| 杜鹏程,谷九莲,韩 璠.埃索美拉唑四联疗法对Hp感染性胃溃疡患者血清MMP-9及TIMP-1的影响[J].中国烧伤创疡杂志,2021,(1):68~71. |
| DOI： |
| 中文关键词: 埃索美拉唑 幽门螺杆菌 胃溃疡 基质金属蛋白酶-9 基质金属蛋白酶抑制剂-1 |
| 英文关键词:Esomeprazole Helicobacter pylori Gastric ulcer MMP-9 TIMP-1 |
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| 中文摘要: |
| 目的 对比观察埃索美拉唑四联疗法与三联疗法对幽门螺杆菌（Hp）感染性胃溃疡患者血清MMP-9及TIMP-1水平的影响。方法 选取2017年9月至2019年9月新乡医学院第三附属医院收治的97例Hp感染性胃溃疡患者作为研究对象，并按照随机数表法将其随机分为研究组（49例）与对照组（48例），其中研究组患者采用埃索美拉唑镁肠溶片、阿莫西林克拉维酸钾片、克拉霉素片、双歧杆菌四联活菌片四联疗法治疗，对照组患者采用埃索美拉唑镁肠溶片、阿莫西林克拉维酸钾片、克拉霉素片三联疗法治疗，对比两组患者治疗前及治疗第7、14天的血清基质金属蛋白酶-9（MMP-9）、基质金属蛋白酶抑制剂-1（TIMP-1）水平以及治疗4周后的临床疗效。结果 治疗第7、14天，研究组患者血清MMP-9、TIMP-1水平均明显低于对照组（MMP-9：t=2.192、5.661，P=0.031、＜0.001；TIMP-1：t=3.749、4.331，P均＜0.001）；治疗4周后，研究组患者治疗总有效率为93.88%，明显高于对照组患者的治疗总有效率81.25%（Z=-2.497，P=0.013）。结论 与埃索美拉唑三联疗法相比，埃索美拉唑四联疗法能够更有效根除Hp，促进Hp感染性胃溃疡愈合，且降低Hp感染性胃溃疡患者血清MMP-9和TIMP-1水平可能是其作用机制，值得临床进一步研究证实。 |
| 英文摘要: |
| 【Abstract】Objective To observe and compare the effect of esomeprazole quadruple therapy and esomeprazole triple therapy on serum levels of MMP-9 and TIMP-1 in patients with Helicobacter pylori (Hp) infected gastric ulcer. Methods Ninety-seven patients with Hp infected gastric ulcers, admitted to the Third Affiliated Hospital of Xinxiang Medical University from September 2017 to September 2019, were selected as research subjects and divided, according to the random number table, into a study group (49 cases) and a control group (48 cases). The patients in the study group were treated with the quadruple therapy consisting of esomeprazole magnesium enteric-coated tablet, amoxicillin and clavulanate potassium tablet, clarithromycin tablet and bifidobacterium tetravaccine tablet. In contrast, the patients in the control group were treated with the triple therapy consisting of esomeprazole magnesium enteric-coated tablet, amoxicillin and clavulanate potassium tablet, and clarithromycin tablet. The serum levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) before treatment and on day 7 and 14 of treatment，and clinical efficacy after 4 weeks of treatment were compared between the two groups. Results On day 7 and 14 of treatment, the serum levels of MMP-9 and TIMP-1 in the study group were significantly lower than that in the control group (MMP-9: t=2.192, 5.661, P=0.031, P<0.001; TIMP-1: t= 3.749, 4.331, both P<0.001). After 4 weeks of treatment, the total effective rate in the study group was 93.88%, which was markedly higher than 81.25% in the control group (Z=-2.497, P=0.013). Conclusion Compared with the triple therapy, the quadruple therapy is more effective in eradicating H. pylori and promoting the healing of Hp infected gastric ulcer. Its mechanism of action might lie in the fact that it can reduce the serum levels of MMP-9 and TIMP-1 in such patients, for which further clinical study is needed to confirm. |
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