| 段 琼,王 剑,梁红伟,王廷金.MEBT/MEBO联合脂肪源性干细胞治疗慢性难愈合创面的疗效[J].中国烧伤创疡杂志,2021,(2):82~85. |
| DOI： |
| 中文关键词: 烧伤创疡再生医疗技术 脂肪源性干细胞 湿润烧伤膏 慢性难愈合创面 |
| 英文关键词:MEBT/MEBO Adipose-derived stem cells MEBO Chronic refractory wounds |
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| 中文摘要: |
| 目的 对比分析烧伤创疡再生医疗技术（MEBT/MEBO）联合脂肪源性干细胞治疗慢性难愈合创面的疗效。方法 选取2017年9月至2019年8月郑州人民医院收治的72例慢性难愈合创面患者作为研究对象，并按照随机数表法将其随机分为研究组（36例）与对照组（36例），其中研究组患者采用MEBT/MEBO联合脂肪源性干细胞治疗局部创面，对照组患者单纯采用MEBT/MEBO治疗局部创面，对比观察治疗第4、8周时两组患者的临床疗效及创面最终愈合时间。结果 治疗第4周，研究组患者中创面痊愈5例、显效19例、有效10例、无效2例，明显优于对照组患者的创面痊愈1例、显效9例、有效12例、无效14例（Z=-3.832，P＜0.001）。治疗第8周，研究组患者中创面痊愈26例、显效7例、有效3例，明显优于对照组患者的创面痊愈8例、显效11例、有效17例（Z=-4.463，P＜0.001）。最终两组患者创面均完全愈合，其中研究组患者创面愈合时间为（39.85±22.48）d，明显短于对照组患者的创面愈合时间（67.66±31.89）d（t=4.277，P＜0.001）。结论 MEBT/MEBO联合脂肪源性干细胞可有效促进慢性难愈合创面愈合，缩短创面愈合时间，提高临床治疗效果。 |
| 英文摘要: |
| 【Abstract】Objective To compare and analyze the clinical efficacy of MEBT/MEBO combined with adipose-derived stem cells in the treatment of chronic refractory wounds. Methods Seventy-two patients with chronic refractory wounds，admitted to People’s Hospital of Zhengzhou from September 2017 to August 2019，were selected as the research subjects to be divided，according to the random number table，into a study group (36 cases) and a control group (36 cases). The patients in the study group were treated with MEBT/MEBO combined with adipose-derived stem cells，while the patients in the control group were treated with MEBT/MEBO only. The clinical efficacy at week 4 and 8 of treatment and the final wound healing time were observed and compared between the two groups. Results At week 4 of treatment，5 cases were cured，19 cases showed markedly effective，10 cases effective and 2 cases ineffective in the study group，which was significantly better than that in the control group (1 case cured，9 cases markedly effective，12 cases effective and 14 cases ineffective. Z=-3.832，P<0.001). At week 8 of treatment，26 cases were cured，7 cases presented markedly effective and 3 cases effective in the study group，much better than 8 cases cured，11 cases markedly effective，and 17 cases effective in the control group (Z=-4.463，P<0.001 ). In the end，the wounds of patients in the two groups were all healed completely. The wound healing time in the study group was (39.85±22.48) d，which was significantly shorter than (67.66±31.89) days in the control group (t=4.277，P<0.001). Conclusion MEBT/MEBO combined with adipose-derived stem cells can effectively promote the healing of chronic refractory wounds and shorten the wound healing time，improving clinical curative effect. |
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