| 魏德华,陈世玖,王成.MEBT/MEBO治疗糖尿病性溃疡作用机制及其相关信号通路研究进展[J].中国烧伤创疡杂志,2021,(3):153~157. |
| DOI： |
| 中文关键词: 糖尿病性溃疡 烧伤创疡再生医疗技术 信号通路 作用机制 |
| 英文关键词:Diabetic ulcer Regenerative medical technology for burns,wounds and ulcers Signaling pathway Mechanism of action |
| 基金项目:中国红十字基金会徐荣祥再生生命公益基金(2019 第 292 号) |
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| 中文摘要: |
| 【摘要】糖尿病性溃疡的临床发病率较高，且发病机制较为复杂? 愈合过程较为缓慢，已成为临床上需要 迫切解决的难题? 近年来，烧伤创疡再生医疗技术(MEBT/ MEBO) 等中医疗法在提高糖尿病性溃疡治疗效果? 降低患者截肢率方面取得了较为显著的临床疗效? 但相关研究资料显示，中医药作为我国传统的治疗方式虽具有其独特的优势，可临床上仅13%的患者会在治疗过程中联合应用? 为提高中医药的关注度以及指导糖尿病性溃 疡的临床治疗? 为MEBT/ MEBO 治疗糖尿病性溃疡提供理论支持，笔者通过查阅大量基础研究资料，对 MEBT/MEBO通过调节 PI3K/ Akt 信号通路? MAPK 信号通路? Wnt/β?catenin 信号通路? TGF?β1 / Smad 信号通路? NF?κB 信号通路和 PI3K/ Akt / mTOR 信号通路的转导而参与糖尿病性溃疡修复的作用机制进行了综述? |
| 英文摘要: |
| 【Abstract】In clinical practice，diabetic ulcer featuring a high incidence，complicated pathogenesis and slow healing process has become a pressing clinical difficulty. In recent years，the regenerative medical technology for burns，wounds and ulcers(MEBT/MEBO) has achieved significant clinical effect in improving the treatment of diabetic ulcers and reducing the amputation rate of such patients. According to relevant research data，though traditional Chinese medicine，as a traditional treatment in our country for a long time，has its unique advantages，it has seldom been integrated into the overall treatment protocol of patients(only 13%). In order to increase people’s awareness of traditional Chinese medicine，offer guidance to the treatment of diabetic ulcers，and provide theoretical support for the treatment of diabetic ulcers with MEBT/MEBO，the author，based on extensive basic studies，made a review on the action of mechanism of MEBT/MEBO in repairing diabetic ulcer by regulating the transduction of such signaling pathways as PI3K/Akt，MAPK，Wnt/β-catenin，TGFβ1/Smad，NF-κB and PI3K/Akt/mTOR. |
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