| 张晓辉.克银丸联合阿维A胶囊对银屑病患者IL⁃17､ TNF⁃α､IFN⁃γ､MDA､TAC的影响[J].中国烧伤创疡杂志,2021,(4):287~290. |
| DOI： |
| 中文关键词: 克银丸 阿维A胶囊 银屑病 炎症反应 氧化应激 |
| 英文关键词:Ke Yin Wan Acitretin Capsules Psoriasis Inflammatory response Oxidative stress |
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| 中文摘要: |
| 【摘要】 目的 探讨克银丸与阿维 A 胶囊联合治疗银屑病的临床疗效及其对白细胞介素?17 ( IL?17)? 肿瘤坏死因子?α (TNF?α)、γ 干扰素 (IFN?γ)、丙二醛 (MDA)、总抗氧化能力 (TAC) 水平的影响? 方法 选取2017年9月至2019年5月台前县夹河中心乡卫生院收治的 104 例血热型寻常型银屑病患者作为研究对象，并按照治疗方法将其分为观察组 (52例) 和对照组 (52例)，对照组患者单纯服用阿维 A 胶囊治疗，观察组患者同 时服用克银丸与阿维 A 胶囊治疗, 对比两组患者临床疗效? 银屑病皮损面积和严重程度指数 (PASI) 评分以及 IL?17、TNF?α、IFN?γ、MDA、TAC 水平变化情况? 结果 治疗8 周后, 观察组患者治愈12 例、显效17 例、有效 18 例、无效 5 例，明显优于对照组患者的治愈 7 例、显效 14 例、有效 18 例、无效 13 例 (Z = - 2. 061, P = 0. 039)；治疗 8 周后, 观察组患者 PASI 评分为 (4. 29 ± 1. 11) 分, 明显低于对照组患者的 PASI 评分 (8. 50 ± 1. 54) 分 (t = 15. 900, P < 0. 001); 治疗 8 周后, 观察组患者血清 IL?17、 TNF?α、 IFN?γ、 MDA 水平均明显低于对照组，TAC 水平明显高于对照组 (t = 34. 360、22. 660、7. 734、18. 480、4. 955，P 均 < 0. 001)? 结论 与单纯应用阿维 A 胶囊相比，克银丸与阿维 A 胶囊联合应用可有效减轻银屑病患者炎症反应及氧化应激反应，提高患者免疫功能，更有利于银屑病皮损症状的消退，提高治疗效果。 |
| 英文摘要: |
| 【Abstract】 Objective To investigate the clinical efficacy of Ke Yin Wan combined with Acitretin Capsules in treating psoriasis, and their effect on the levels of leukocyte interleukin?17 (IL?17), tumor necrosis factor?α (TNF?α), γ interferon (IFN?γ), malondialdehyde (MDA), and total antioxidant capacity (TAC). Methods One hundred and four patients with psoriasis vulgaris of blood?heat type, admitted to Jiahe Central Township Health Center from September 2017 to May 2019, were selected as study subjects, and they were divided into an observation group (52 cases) and a control group (52 cases) according to the different treatment methods they received. Patients in the control group were simply administered Acitretin Capsules for treatment, whereas patients in the observation group took Ke Yin Wan and Acitretin Capsules. The clinical efficacy, psoriasis area and severity index (PASI) score, and changes of IL?17, TNF?α, IFN?γ, MDA, TAC levels were compared between the two groups. ResultsAfter 8 weeks of treatment, 12 cases were cured, 17 cases showedmarkedly effective, 18 cases showed effective and 5 cases ineffective in the observation group, which was obviously superior to the 7 cases cured, 14 cases markedly effective, 18 cases effective and 13 cases ineffective in the control group (Z = -2. 061, P = 0. 039). After 8 weeks of treatment, the PASI score in the observation group was (4. 29 ± 1. 11) points, which was obviously lower than (8. 50 ± 1. 54) points in the control group ( t = 15. 900, P < 0. 001), and moreover, the levels of serum IL?17, TNF?α, IFN?γ and MDA in the observation group were all significantly lower than that in the control group, while the TAC level in the observation group was significantly higher than that in the control group ( t = 34. 360, 22. 660, 7. 734, 18. 480 and 4. 955, all P < 0. 001). Conclusion Compared with the simple application of Acitretin Capsules, the combined application of Ke Yin Wan and Acitretin Capsules can effectively reduce the inflammatory reaction and oxidative stress response of patients with psoriasis, improve their immune function, and much facilitate the fading away of skin symp? toms, achieving good therapeutic effect. |
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