| 陈壮丽,卢 维,李杰辉.GM-CSF在慢性难愈合创面中的应用研究进展[J].中国烧伤创疡杂志,2021,(6):385~388. |
| DOI： |
| 中文关键词: 粒细胞-巨噬细胞集落刺激因子 创面 修复 应用研究 综述 |
| 英文关键词:Granulocyte-macrophage colony stimulating factor Wound Repair Application study Review |
| 基金项目:国家自然科学基金(81660793)；广西科技重点研发项目(桂科AB17292046)；广西中医药大学校级科研创新项目(YCSY2020055) |
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| 中文摘要: |
| 【摘要】 粒细胞-巨噬细胞集落刺激因子(GM-CSF) 作为一种多功能造血因子，可刺激造血前体细胞增殖、分化，并促进其向外周转移；作为重要的炎症细胞趋化和活化因子，可刺激上皮细胞?成纤维细胞等创面修复细胞的增殖、分化以及血管内皮生长因子等相关生长因子的分泌，调控创面修复，与创面愈合过程密切相关。且近年来部分研究显示，GM-CSF在慢性难愈合创面的修复中取得了一定的临床疗效。基于此，为进一步指导GM-CSF在慢性难愈合创面中的治疗，本文对其应用研究进展予以综述。 |
| 英文摘要: |
| 【Abstract】Granulocyte-macrophage colony stimulating factor (GM-CSF)，a multifunctional hematopoietic factor，can stimulate the proliferation and differentiation of hematopoietic precursor cells，and promote their peripheral migration. As an important chemotacticactivating factor of inflammatory cells，GM-CSF can stimulate the proliferation and differentiation of cells playing a role in wound repair including epithelial cells and fibroblasts and the secretion of some growth-related factors including vascular endothelial growth factors， to regulate the process of wound repair，which is closely associated with wound healing. In recent years，some studies have shown that GM-CSF has certain clinical efficacy in repairing chronic refractory wounds. Based on this，this article made a review on the research progress of GM-CSF in repairing chronic refractory wounds for its better application in clinical practice. |
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