| 高海霞,李 民.自体微粒皮种植联合MEBT/MEBO治疗难愈性烧伤残余创面疗效观察[J].中国烧伤创疡杂志,2021,(6):392~394. |
| DOI： |
| 中文关键词: 自体微粒皮种植 烧伤创疡再生医疗技术 湿润烧伤膏 难愈性烧伤残余创面 瘢痕 |
| 英文关键词:Autologous microskin implantation Regenerative medical technology for burns, wounds and ulcers MEBO Refractory residual burn wounds Scars |
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| 中文摘要: |
| 【摘要】目的 分析自体微粒皮种植联合烧伤创疡再生医疗技术（MEBT/MEBO）治疗难愈性烧伤残余创面的临床疗效。方法 选取2019年1月至2020年6月南方医科大学附属南海医院收治的20例难愈性烧伤残余创面患者作为研究对象，按照随机数表法将其随机分为试验组（10例）和对照组（10例），其中试验组患者采用自体微粒皮种植联合MEBT/MEBO治疗，对照组患者单纯采用MEBT/MEBO治疗，对比两组患者临床疗效、创面愈合时间及瘢痕增生情况。结果 治疗4周后，试验组患者中显效8例、有效2例，明显优于对照组患者的显效2例、有效2例、无效6例（Z=-2.966，P=0.003）；试验组患者创面愈合时间为（29.40±8.77）d，明显短于对照组患者的创面愈合时间（49.60±16.22）d（t=3.464，P=0.003）；创面愈合后6个月随访，试验组患者中轻度瘢痕增生3例、中度瘢痕增生6例、重度瘢痕增生1例，明显轻于对照组患者的轻度瘢痕增生1例、中度瘢痕增生2例、重度瘢痕增生7例（Z=-2.437，P=0.015）。结论 自体微粒皮种植联合MEBT/MEBO治疗难愈性烧伤残余创面可缩短创面愈合时间，改善瘢痕增生情况，疗效显著，值得临床推广应用。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the clinical efficacy of autologous microskin implantation combined with regen-erative medical technology for burns， wounds and ulcers (MEBT/ MEBO) in the treatment of refractory residual burnwounds. Methods 20 patients with refractory residual burn wounds， admitted to Nanhai District People’s Hospital of Foshan from January 2019 to January 2020， were enrolled and divided into experiment group ( n = 10) and control group (n =10) using random number table. Patients in experiment group were treated with autologous microskin implanta?tion combined with MEBT/ MEBO， whereas patients in control group with MEBT/ MEBO only. The clinical efficacy， wound healing time and scar formation were compared between the two groups. Results After 4 weeks of treatment， 8 cases were markedly effective and 2 cases were effective in experiment group， which was significantly better than control group (Z =-2. 966， P =0. 003) in which 2 cases were markedly effective， 2 cases were effective and 6 cases were ineffective. The wound healing time in experiment group was (29. 40±8.77) days， significantly shorter than (49. 60 ±16. 22) days in control group (t=3.464，P =0.003). At 6-month follow-up， 3 cases developed moderate and mild scar hyperplasia，6 cases mod-erate scar hyperplasia， and 1 case severe scar hyperplasia in experiment group， which was significantly superior to control group (Z=-2.437，P=0.015) in which 1 case developed mild scar hyperplasia，2 cases moderate scar hyperplasia， and 7 cases severe scar hyperplasia. Conclusion Autologous microskin implantation combined with MEBT/ MEBO in the treatment of refractory residual burn wounds can shorten wound healing time and lessen scar hyperplasia， deserving to be promoted in clinical practice. |
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