| 吴爱玲.自拟中药汤剂口服联合湿润烧伤膏灌肠在溃疡性结肠炎中的应用效果研究[J].中国烧伤创疡杂志,2022,(1):62~66. |
| DOI： |
| 中文关键词: 自拟中药汤剂 湿润烧伤膏 溃疡性结肠炎 灌肠 肠道黏膜损害 |
| 英文关键词:Hospital-made traditional Chinese medicine decoction MEBO Ulcerative colitis Enema Intestinal mucosal damage |
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| 中文摘要: |
| 【摘要】 目的 分析自拟中药汤剂口服联合湿润烧伤膏灌肠治疗溃疡性结肠炎的临床疗效。方法 选取2017年3月至2020年3月上蔡县人民医院收治的73 例溃疡性结肠炎患者作为研究对象，并按照治疗方法将其分为研究组(37例)和对照组(36例)，研究组患者采用自拟中药汤剂口服联合湿润烧伤膏灌肠治疗，对照组患者单纯采用湿润烧伤膏灌肠治疗，对比两组患者临床疗效、临床症状评分、溃疡性结肠炎内镜下严重性评分、溃疡性结肠炎活动指数(DAI)评分以及不良反应发生情况。结果 治疗4 周后，研究组患者总有效率为94.59%,明显高于对照组患者的总有效率77.78% (χ2 =4.365，P =0.037)；研究组患者腹痛?腹泻?脓血便?里急后重评分以及溃疡性结肠炎内镜下严重性与DAI 评分均低于对照组(t= 17.504、17.525、17.417、17.357、17.575、16.977，P均<0.001)。治疗期间，研究组患者均未出现不良反应，明显低于对照组患者的不良反应发生率11.11% (χ2 =4.349，P =0.037)。结论 自拟中药汤剂口服联合湿润烧伤膏灌肠治疗溃疡性结肠炎，可提高患者临床疗效，改善临床症状，减轻肠道黏膜损害，且不良反应较少，临床应用价值较高。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the clinical efficacy of oral administration of hospital?made traditional Chinese medicine decoction and enema with MEBO in treating ulcerative colitis. Methods 73 patients with ulcerative colitis，admitted to Shangcai People’s Hospital from March 2017 to March 2020，were enrolled and divided into study group (n=37)and control group (n=36) based on different treatments they received. Patients in study group were treated with Orally-administrated hospital-made traditional Chinese medicine decoction and enema with MEBO， whereas patients in control group only underwent enema with MEBO.The clinical efficacy，clinical symptoms score， ulcerative colitis endoscopic index of severity，disease activity index (DAI) score and occurrence of adverse reactions were compared between the two groups. Results After 4 weeks of treatment， the total effective rate in study group was 94.59%， much higher than 77.78% in control group (χ2 =4.365， P=0.037); scores of abdominal pain， diarrhea， bloody purulent stool， tenesmus，ulcerative colitis endoscopic index of severity and DAI in study group were all lower than control group (t= 17.504，17.525，17.417，17.357，17.575 and 16.977，all P <0.001). During the course of treatment， no adverse reactions was observed in study group， and thus its incidence of adverse reactions was much lower than 11.11% in control group (χ2 =4.349， P <0.037). Conclusion Oral administration of hospital-made traditional Chinese medicine decoction and enema with MEBO in the treatment of ulcerative colitis can improve the clinical efficacy and clinical symptoms of patients， alleviate damage on intestinal mucosa. Moreover， the protocol rarely causes adverse reactions and has a high value of application in clinical practice. |
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