| 窦阳旭,张鹏飞.兰索拉唑与法莫替丁三联疗法治疗胃溃疡疗效对比[J].中国烧伤创疡杂志,2022,(1):67~70. |
| DOI： |
| 中文关键词: 兰索拉唑 法莫替丁 胃溃疡 丙二醛 一氧化氮 超氧化物歧化酶 |
| 英文关键词:Lansoprazole Famotidine Gastric ulcer Malondialdehyde Nitric oxide Superoxide dismutase |
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| 中文摘要: |
| 【摘要】 目的 对比观察兰索拉唑三联疗法与法莫替丁三联疗法治疗胃溃疡的临床疗效?方法 选取2019年7月至2020年7月丹东市中心医院收治的80例胃溃疡患者作为研究对象，并按照随机数表法将其随机分为兰索拉唑组与法莫替丁组，每组40例，兰索拉唑组采用兰索拉唑+阿莫西林+克拉霉素三联疗法治疗，法莫替丁组采用法莫替丁+阿莫西林+克拉霉素三联疗法治疗，对比观察两组患者临床症状评分，血清丙二醛(MDA)、一氧化氮(NO)、超氧化物歧化酶(SOD)水平变化情况以及临床疗效?结果 治疗2个月后，兰索拉唑组患者胃胀、反酸、腹痛及恶心评分均明显低于法莫替丁组(t=4.101、8.560、4.874、4.764，P均<0.001); MDA水平明显低于法莫替丁组，NO与SOD水平明显高于法莫替丁组(t=4.183、5.946、5.892，P均<0.001);兰索拉唑组患者中显效27例、有效11例、无效2例，明显优于法莫替丁组患者的显效14 例、有效19 例、无效7例(Z = -2.986，P=0.003)。结论 与法莫替丁三联疗法相比，兰索拉唑三联疗法能够有效调节MDA、NO及SOD水平，减轻临床症状，促进胃溃疡愈合，疗效更显著? |
| 英文摘要: |
| 【Abstract】 Objective To compare the clinical efficacy of Lansoprazole triple therapy and Famotidine triple therapy in the treatment of gastric ulcer. Methods 80 patients with gastric ulcers, admitted to Dandong Central Hospital from July 2019 to July 2020, were enrolled as research subjects and divided, using random number table, into Lansoprazole group (n =40) and Famotidine group (n =40). The patients in Lansoprazole group were treated with the triple therapy of Lansoprazole + Amoxicillin + Clarithromycin, while the patients in the Famotidine group were treated with the triple therapy of Famotidine + Amoxicillin + Clarithromycin. Clinical symptoms score, changes of Malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD), and clinical efficacy were compared between the two groups.Results After 2 months of treatment, as compared with Famotidine group, the scores of gastric distention, sour regurgitation, abdominal pain and nausea in Lansoprazole group were significantly lower (t = 4.101, 8.560, 4.874 and 4.764, all P < 0.001),MDA level was obviously lower and the levels of NO and SOD were much higher (t = 4.183, 5.946, 5.892, all P <0.001). In Lansoprazole group, the treatment was markedly effective in 27 cases, effective in 11 cases and ineffective in 2 cases, significantly better than Famotidine group in which the treatment was markedly effective in 14 cases, effective in 19cases, and ineffective in 7 cases (Z = - 2.986, P = 0.003). Conclusion Compared with Famotidine triple therapy,Lansoprazole triple therapy showed better therapeutic effects by effectively regulating the levels of MDA, NO and SOD, alleviating clinical symptoms and promoting the healing of gastric ulcers. |
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