| 李明奚,秦勤召.雷尼替丁对老年复发性口腔溃疡患者血清IFN-γ、TNF-α、IL-2水平的影响[J].中国烧伤创疡杂志,2022,(2):89~92. |
| DOI： |
| 中文关键词: 雷尼替丁 复发性口腔溃疡 γ-干扰素 肿瘤坏死因子-α 白细胞介素-2 |
| 英文关键词:Ranitidine Recurrent oral ulcer Interferon-γ Tumor necrosis factor-α |
| 基金项目: |
|
| 摘要点击次数: 1628 |
| 全文下载次数: 4626 |
| 中文摘要: |
| 【摘要】 目的 探讨雷尼替丁治疗老年复发性口腔溃疡的临床疗效及其对患者血清γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-2 (IL-2)水平的影响。方法 选取2019年7月至2020年11月丹东市人民医院收治的70例老年复发性口腔溃疡患者作为研究对象，按照随机数表法将其随机分为观察组(35例)和对照组(35例)，观察组患者在冰硼散联合维生素C治疗的基础上加用雷尼替丁治疗，对照组患者采用冰硼散联合维生素C治疗，对比两组患者IFN-γ、TNF-α、IL-2水平变化情况以及临床疗效与不良反应发生情况。结果 治疗7 d后，观察组患者IFN-γ水平为(77.18±11.39) mmol/L，明显高于对照组患者的IFN-γ(63.18±12.39) mmol/L (t =4.921，P＜0.001)；TNF-α水平为(2.78±0.42)mg/ ml、IL-2水平为(0.25±0.06)mg/ml，明显低于对照组患者的TNF-α水平(5.97±1.46) mg/ml、IL-2水平(0.73±0.10) mg/ ml (t=12.420、24.350，P 均＜0.001)。治疗7 d后，观察组患者总有效率为97.14%，明显高于对照组患者的总有效率82.86% (χ2=3. 968，P=0.046)?治疗过程中，观察组患者不良反应发生率为11.43%，与对照组患者的不良反应发生率11.43%无明显差异(χ2 =0.000，P =1.000)。结论 雷尼替丁治疗老年复发性口腔溃疡，可明显改善机体IFN-γ、TNF-α、IL-2等因子的表达水平，提高临床疗效，且安全性较高，值得临床推广应用。 |
| 英文摘要: |
| 【Abstract】 Objective To investigate the clinical efficacy of Ranitidine in treating recurrent oral ulcer in elderly patients，and its influence on expression of serum interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α) and interleukin-2(IL-2)of such patients. Methods 70 elderly patients with recurrent oral ulcer, admitted to Dandong People’s Hospital between July 2019 and November 2020， were enrolled and divided, using the random number table，into study group (n=35) and control group (n =35).Patients in study group were treated with Bingpeng San and Vitamin C plus Ranitidine，whereas patients in control group were treated with Bingpeng San and Vitamin C. The changes of IFN-γ，TNF-αand IL-2，clinical efficacy and occurrence of adverse reactions were compared between the two groups. Results After 7 days of treatment，the level of IFN-γ was (77.18±11.39)mmol/L in study group， obviously higher than (63.18±12.39) mmol/L incontrol group (t=4.921，P＜0.001)，and the levels of TNF-α and IL-2 were respectively (2.78±0.42) mg/ml and(0.25 ±0.06) mg/ ml，significantly lower than the corresponding (5.97±1.46) mg/ ml and (0.73±0.10)mg/ ml in control group (t=12.420 and 24.350，both P＜0.001). After 7 days of treatment，the total effective rate in study group was 97.14%，remarkably higher than 82.86% in control group (χ2 =3.968，P=0.046).During the course of treatment，the incidence of adverse reactions in study group was 11.43%，which showed no statistically significant difference as compared with 11.43% in control group (χ2 =0.000, P =1.000).Conclusion In the treatment of recurrent oral ulcer in elderly patients，Ranitidine can significantly ameliorate the expression of serum IFN-γ，TNF-αand IL-2，and improve clinical efficacy. Besides，it is very safe，deserving to be promoted in clinical practice. |
|
