• 重度烧伤患者并发脓毒症的危险因素分析
  • Analysis of Risk Factors for Sepsis in Severely Burned Patients
  • 孙留涛.重度烧伤患者并发脓毒症的危险因素分析[J].中国烧伤创疡杂志,2022,(2):97~100.
    DOI:
    中文关键词:  重度烧伤  脓毒症  危险因素  降钙素原  可溶性髓系细胞触发受体-1  CD64  肿瘤坏死因子-α
    英文关键词:Severe burn  Sepsis  Risk factor  Procalcitonin (PCT)  Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1)  CD64  Tumor necrosis factor-α
    基金项目:
    作者单位
    孙留涛 475300 河南 开封兰考第一医院呼吸及危重症科 
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    中文摘要:
          【摘要】 目的 分析重度烧伤患者并发脓毒症的危险因素。方法 选取2017年1月至2020年7月兰考第一医院收治的138例重度烧伤患者作为研究对象,收集患者性别、年龄、烧伤原因、烧伤至入院时间、烧伤面积、是否合并吸入性损伤情况及休克以及血浆降钙素原(PCT)、溶性髓系细胞触发受体-1(sTREM-1)、CD64、肿瘤坏死因子-α(TNF-α)水平等资料,根据是否并发脓毒症将患者分为脓毒症组和非脓毒症组,多因素Logistic回归分析重度烧伤患者并发脓毒症的相关危险因素。结果 138例重度烧伤患者并发脓毒症者59例,设为脓毒症组;未并发脓毒症者79例,设为非脓毒症组。多因素Logistic回归分析结果显示,烧伤面积>50% TBSA、合并吸入性损伤及休克、血浆PCT≥2.0 μg/L以及高水平sTREM-1、CD64、TNF-α是重度烧伤后并发脓毒症的独立危险因素(95% CI为1.133~1.351、1.189~1.505、1.115~13.754、1.077~14.942、1.294~3.714、1.249~5.082、1.141~5.826)。结论 重度烧伤患者并发脓毒症的发生风险与烧伤面积、吸入性损伤、休克以及血浆PCT、sTREM-1、CD64、TNF-α水平密切相关。
    英文摘要:
          【Abstract】 Objective To analyze the risk factors for sepsis in severely burned patients. Methods 138 patients with severe burns, admitted into Lankao First Hospital between January 2017 and July 2020, were enrolled as research subjects and divided into sepsis group and non-sepsis group based on whether sepsis occurred, and data including sex, age,cause of burns, time between injury and hospital admission, burned surface area, with inhalation injury and shock or not,levels of Procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells-1(sTREM-1), CD64 and tumor necrosis factor-α(TNF-α) were collected to analyze the relevant risk factors for sepsis in severely burned patients using multivariate Logistic regression analysis.Results Of the 138 severely burned patients, 59 cases with sepsis were set as sepsis group, and the other 79 cases without sepsis were set as non-sepsis group. Multivariate Logistic regression analysis foundthat burned surface area >50% TBSA, with inhalation injury and shock, plasma PCT≥2.0μg/L,high-level sTREM-1,CD64 and TNF-αwere independent risk factors of sepsis in severely burned patients (95%CI:1.133-1.351,1.115-13.754,1.18-1.505,1.077-14.942,1.294-3.714,1.249-5.082 and 1.141-5.826, P=0.001,0.003,0.001, 0.038, 0.003, 0.009 and 0.022). Conclusion The occurrence of sepsis in severely burned patients was closely associated with such factors as burned surface area, inhalation injury, shock, and levels of plasma PCT, sTREM-1, CD64 and TNF-α.