【Abstract】 Objective To analyze the risk factors for sepsis in severely burned patients. Methods 138 patients with severe burns, admitted into Lankao First Hospital between January 2017 and July 2020, were enrolled as research subjects and divided into sepsis group and non-sepsis group based on whether sepsis occurred, and data including sex, age,cause of burns, time between injury and hospital admission, burned surface area, with inhalation injury and shock or not,levels of Procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells-1(sTREM-1), CD64 and tumor necrosis factor-α(TNF-α) were collected to analyze the relevant risk factors for sepsis in severely burned patients using multivariate Logistic regression analysis.Results Of the 138 severely burned patients, 59 cases with sepsis were set as sepsis group, and the other 79 cases without sepsis were set as non-sepsis group. Multivariate Logistic regression analysis foundthat burned surface area >50% TBSA, with inhalation injury and shock, plasma PCT≥2.0μg/L,high-level sTREM-1,CD64 and TNF-αwere independent risk factors of sepsis in severely burned patients (95%CI:1.133-1.351,1.115-13.754,1.18-1.505,1.077-14.942,1.294-3.714,1.249-5.082 and 1.141-5.826, P=0.001,0.003,0.001, 0.038, 0.003, 0.009 and 0.022). Conclusion The occurrence of sepsis in severely burned patients was closely associated with such factors as burned surface area, inhalation injury, shock, and levels of plasma PCT, sTREM-1, CD64 and TNF-α. |