| 郑双全.富血小板血浆联合负压封闭引流在慢性难愈合创面中的应用效果分析[J].中国烧伤创疡杂志,2022,(3):174~178. |
| DOI： |
| 中文关键词: 慢性难愈合创面 富血小板血浆 负压封闭引流 组织型纤溶酶原激活物 尿激酶型纤溶酶原激活物 红细胞沉降率 C反应蛋白 |
| 英文关键词:Chronic refractory wound Platelet-rich plasma Vacuum sealing drainage Tissue-type plasminogen activator Urokinase-type plasminogen activator Erythrocyte sedimentation rate C-reaction protein |
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| 中文摘要: |
| 【摘要】 目的 探讨富血小板血浆(PRP)联合负压封闭引流(VSD)在慢性难愈合创面治疗中的临床效果?方法 选取2019年8月至2020年8月方城县人民医院收治的64例慢性难愈合创面患者作为研究对象,按照随机数表法将其随机分为研究组(32例)与对照组(32例),研究组患者采用PRP联合VSD治疗,对照组患者单纯采用VSD治疗,对比两组患者红细胞沉降率(ESR)、C反应蛋白(CRP)、组织型纤溶酶原激活物(t-PA)、尿激酶型纤溶酶原激活物(u-PA)水平变化情况,创面愈合时间及愈后皮肤瘢痕增生情况?结果 治疗7d后,研究组患者ESR水平为(18.27±1.83)mm/h、CRP水平为(2.15±0.22)g/L,明显低于对照组患者的ESR水平(24.26±2.43)mm/h、CRP水平(3.04±0.31)g/L(t=11.139、13.244,P均＜0.001)；t-PA水平为(62.18±6.22)ng/ml、u-PA水平为(621.56±62.16)pg/ml,明显高于对照组患者的t-PA水平(55.46±5.55)ng/ml、u-PA水平(586.36±58.64)pg/ml(t=4.560、2.330,P＜0.001、P=0.023)?研究组患者创面愈合时间为(12.98±1.31)d,明显短于对照组患者的创面愈合时间(16.57±1.67)d(t=9.568,P＜0.001)?创面愈合后3个月,研究组患者愈后皮肤温哥华瘢痕量表(VSS)评分为(5.38±0.54)分,明显低于对照组患者的VSS评分(7.56±0.76)分(t=13.227,P＜0.001)?结论 PRP联合VSD治疗慢性难愈合创面,可有效改善ESR、CRP、t-PA、u-PA水平,缩短创面愈合时间,减轻愈后皮肤瘢痕增生程度? |
| 英文摘要: |
| 【Abstract】 Objective To study the clinical efficacy of platelet-rich plasma (PRP) combined with vacuum sealing drainage (VSD) in the treatment of chronic refractory wounds. Methods 64 patients with chronic refractory wounds,admitted into Fangcheng People’s Hospital between August 2019 and August 2020 were enrolled as research subjects to be divided into study group (n = 32) and control group (n = 32) using the random number table. Patients in study group were treated with PRP and VSD, while patients in control group were treated with VSD only. Changes of erythrocyte sedimentation rate (ESR), C-reaction protein (CRP), tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), wound healing time and scar hyperplasia condition on healed skin were compared between the two groups.Results After 7 days of treatment, the levels of ESR and CRP of patients were respectively (18.27±1.83) mm/ h and (2.15±0.22) g / L in study group, obviously lower than the corresponding (24.26 ± 2.43) mm/ h and (3.04±0.31) g / L in control group ( t = 11.139 and 13.244, both P＜0.001) .The levels of t-PA and u-PA were respectively (62.18±6.22) ng / ml and (621.56±62.16) pg / ml in study group, remarkably higher than the corresponding (55.46 ± 5.55) ng / ml and (586.36 ± 58.64) pg / ml in control group ( t = 4.560 and 2.330, P＜0.001, P = 0.023). The wound healing time was (12.98 ± 1.31) d in study group, obviously shorter than (16.57 ± 1.67) d in control group (t = 9.568, P＜0.001).Three months after wound healing, the Vancouver scar scale (VSS) score of healed skin was (5.38 ± 0.54) points in study group, significantly lower than (7.56±0.76) points in control group ( t=13.227, P＜0.001). Conclusion The combined application of PRP and VSD in the treatment of chronic refractory wounds can markedly improve the expression levels of ESR, CRP, t-PA and u-PA in wounds, shorten wound healing time and ameliorate scar hyperplasia on healed skin. |
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