欢迎访问中国烧伤创疡杂志网站！

复方倍他米松联合5-氟尿嘧啶在增生性瘢痕中的应用效果分析
Analysis of Clinical Efficacy of Compound Betamethasone Injection Combined with 5⁃fluorouracil in Treating Hypertrophic Scar

黄银浩,龙　航,张艾丽,李德彧,林伟清,桑　明,颜廷凯,方　杰,王　芳.复方倍他米松联合5-氟尿嘧啶在增生性瘢痕中的应用效果分析[J].中国烧伤创疡杂志,2022,(3):209~212.

DOI：

英文关键词:Compound Betamethasone Injection 5-fluorouracil Hypertrophic scar Small size Vancouver scarscale

基金项目:

作者	单位
黄银浩	551700 贵州毕节, 毕节市第一人民医院皮肤科
龙　航	551700 贵州毕节, 毕节市第一人民医院烧伤整形外科
张艾丽	551700 贵州毕节, 毕节市第一人民医院皮肤科
李德彧	551700 贵州毕节, 毕节市第一人民医院皮肤科
林伟清	551700 贵州毕节, 毕节市第一人民医院皮肤科
桑　明	551700 贵州毕节, 毕节市第一人民医院皮肤科
颜廷凯	551700 贵州毕节, 毕节市第一人民医院皮肤科
方　杰	551700 贵州毕节, 毕节市第一人民医院皮肤科
王　芳	551700 贵州毕节, 毕节市第一人民医院皮肤科

摘要点击次数: 1602

全文下载次数: 4676

中文摘要:

【摘要】目的对比分析复方倍他米松联合 5-氟尿嘧啶与单纯复方倍他米松注射治疗小面积增生性瘢痕的临床效果? 方法选取 2018年1月至2019 年7月毕节市第一人民医院收治的36例小面积增生性瘢痕患者作为研究对象, 按照随机数表法将其随机分为观察组与对照组, 每组18例? 观察组患者采用复方倍他米松联合 5-氟尿嘧啶注射治疗, 对照组患者单纯采用复方倍他米松注射治疗, 对比观察两组患者温哥华瘢痕量表 (VSS) 评分及临床疗效? 结果治疗结束后1个月, 观察组患者VSS评分为 (2.00±0.77) 分, 明显低于对照组患者的VSS评分 (6.22±1.93) 分 (t = 8.616, P < 0.001); 随访1年后, 观察组患者中治愈8例、显效10例, 明显优于对照组患者的治愈3例、显效11例、无效4例 (Z = - 2.340, P = 0.019)? 结论与单纯应用复方倍他米松相比,应用复方倍他米松联合5-氟尿嘧啶治疗小面积增生性瘢痕可有效促进瘢痕组织消退, 改善瘢痕症状, 疗效更显著?

英文摘要:

【Abstract】 Objective To analyze the clinical efficacy of Compound Betamethasone Injection combined with 5-fluorouracil in the treatment of small-sized hypertrophic scars. Methods Thirty-six patients with small-sized hypertrophic scars, admitted to the First People’s Hospital of Bijie City from January 2018 to July 2019, were enrolled as research subjects and divided, using random number table, into observation group (n = 18) and control group (n = 18). The patients in observation group were treated with Compound Betamethasone Injection combined with 5-fluorouracil, whereas patients in control group were treated with Compound Betamethasone Injection alone. The Vancouver scar scale (VSS) score and clinical efficacy were compared between the two groups. Results One month after the end of treatment, the VSS score in observation group was (2.00 ± 0.77) points, much lower than (6.22 ± 1.93) points in control group ( t = 8.616, P＜0.001). During the one-year follow-up, 8 cases were cured and 10 cases were markedly effective in observation group,much better than control group with 3 cases cured, 11 cases markedly effective and 4 cases ineffective (Z = - 2.340, P =0.019). Conclusion Compared with application of Compound Betamethasone Injection alone, the combined application of Compound Betamethasone Injection and 5-fluorouracil in the treatment of small-sized hypertrophic scar can significantly promote the regression of scar tissues and improve patients’ scarring symptoms, presenting better clinical efficacy.