| 戚世玲,刘 清,何仁亮,朱定衡,冯 雷,谢志敏,方培炫,朱 璐.MEBO联合微粒皮种植对糖尿病足创面组织中VEGF、EGF表达水平的影响[J].中国烧伤创疡杂志,2022,(4):240~243. |
| DOI： |
| 中文关键词: 湿润烧伤膏 微粒皮种植 糖尿病足 血管内皮生长因子 表皮生长因子 创面 |
| 英文关键词:MEBO Micro-skin grafting Diabetic foot Vascular endothelial growth factor Epidermal growth
factor Wound |
| 基金项目:广州市卫生健康科技项目 (20202A011027) |
|
| 摘要点击次数: 1484 |
| 全文下载次数: 4085 |
| 中文摘要: |
| 【摘要】 目的 探讨湿润烧伤膏 (MEBO) 联合微粒皮种植对糖尿病足创面组织中血管内皮生长因子(VEGF)、表皮生长因子 (EGF) 表达水平的影响。方法 给予2018年1月至2020年12月广州医科大学附属第五医院收治的38例Wagner 2 ~3级糖尿病足患者创面行MEBO联合微粒皮种植治疗，观察创面愈合情况，并对比治疗前与治疗第 7、14 天创面面积以及创面组织中VEGF、EGF含量。结果 治疗2个月后，33例患者创面完全愈合、5例患者创面明显缩小。治疗过程中，38例患者创面组织中VEGF及EGF含量均呈逐渐升高趋势，其中各时间点创面组织中VEGF含量对比差异均具有统计学意义 (q =10.310、23.280、12.970，P均<0.001); EGF含量除治疗前与治疗第7天对比，差异无统计学意义(q =1.797，P =0.945)外，其余各时间点对比，差异均具有统计学意义(q = 12.040、10.240，P 均 < 0.001)。Pearson相关系数分析结果显示，创面组织中VEGF、EGF含量与创面面积无明显相关性(r =0.181、0.205，P =0.833、0.094)。 结论 MEBO联合微粒皮种植促进糖尿病足创面愈合的机制可能与MEBO 能够上调创面组织中VEGF、EGF的表达水平有关。 |
| 英文摘要: |
| 【Abstract】 Objective To investigate the influence of MEBO combined with micro-skin grafting on the expression levels of vascular endothelial growth factor (VEGF) and epidermal growth factor ( EGF) in diabetic foot wounds.Methods 38 patients with diabetic foot of Wagner grade Ⅱ-Ⅲ, admitted into The Fifth Affiliated Hospital of Guangzhou Medical University between January 2018 and December 2020, were treated with MEBO combined with micro-skin grafting.The wound healing condition was observed, and the wound size and expression levels of VEGF and EGF in wound tissues were measured before treatment, and respectively on day 7 and 14 of treatment. Results After 2 months of treatment, the wounds of 33 patients were completely healed and the wound size significantly decreased in the other 5 patients. During the course of treatment, the levels of VEGF and EGF in wound tissues of the 38 patients presented a trend of gradual increase, and the VEGF levels in wound tissues were compared at different time points and the differences were all significant (q =10.310, 23.280 and 12.970, all P <0.001). Except the level of EGF in wound tissues before treatment presenting no significant difference compared with that on day 7 of treatment (q = 1.797, P = 0.945), the comparisons of EGF levels at other different time points showed significantly differences (q =12.040 and 10.240, both P <0.001). Pearson correlation analysis showed that the expression levels of VEGF and EGF in wound tissues had no significant correlation with wound size (r =0.181 and 0.205, P = 0.833 and 0.094). Conclusion The mechanism of the combined application of MEBO and micro-skin grafting in promoting wound healing of diabetic foot may be associated with the elevated expression of VEGF and EGF in wound tissues. |
|
|
|
|
