| 侯 园,王夏婉.艾司奥美拉唑与奥美拉唑四联疗法治疗Hp感染性胃溃疡疗效对比[J].中国烧伤创疡杂志,2022,(5):372~376. |
| DOI： |
| 中文关键词: 艾司奥美拉唑 奥美拉唑 幽门螺杆菌感染性胃溃疡 幽门螺杆菌根除率 胃黏膜血流量 白
细胞介素-8 肿瘤坏死因子-α |
| 英文关键词:Esomeprazole Omeprazole Helicobacter pylori⁃induced gastric ulcer Eradication rate of Helicobacter pylori Gastric mucosal blood flow Interleukin⁃8 Tumor necrosis factor⁃α |
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| 【摘要】 目的 对比分析艾司奥美拉唑四联疗法与奥美拉唑四联疗法治疗幽门螺杆菌(Hp)感染性胃溃疡的临床疗效。方法 选取2020年6月至2021年6月河南科技大学第一附属医院收治的80例 Hp感染性胃溃疡患者作为研究对象,按照随机数表法将其随机分为观察组(40例)与对照组 (40例)。观察组患者采用艾司奥美拉唑四联疗法治疗,对照组患者采用奥美拉唑四联疗法治疗,对比观察两组患者临床症状评分、Hp根除率、胃黏膜血流量 (GMBF)、炎症因子水平以及不良反应发生率。结果 治疗 14 d 后, 观察组患者胃部烧灼痛、胃胀嗳气、恶心呕吐症状评分以及白细胞介素-8(IL-8)、肿瘤坏死因子-α ( TNF-α)水平均明显低于对照组 ( t = 2.775、4.236、4.996、6.509、9.706，P = 0.007、P < 0.001、P < 0.001、P < 0.001、P < 0.001）；Hp根除率为 87.50%明显高于对照组患者的 Hp 根除率 67.50%（χ2 = 4.588，P = 0.032）；胃小弯、胃大弯、胃前壁以及胃后壁 GMBF 均明显高于对照组 (t = 4.529、4.111、4.452，P 均 < 0.001）。其间, 观察组患者不良反应发生率为10.00%与对照组患者的不良反应发生率20.00%无明显差异 ( χ2 = 1.569，P = 0.210）。结论 与奥美拉唑四联疗法相比, 艾司奥美拉唑四联疗法能更有效促进胃黏膜血流恢复, 抑制IL-8、TNF-α分泌,根除Hp,减轻患者临床症状。 |
| 英文摘要: |
| 【Abstract】 Objective To compare the clinical efficacy of the Esomeprazole quadruple therapy and the Omeprazole quadruple therapy in treating Helicobacter pylori (Hp)-induced gastric ulcer. Methods 80 patients with Hp-induced gastric ulcer, admitted to The First Affiliated Hospital of Henan University of Science and Technology from June 2020 to June 2021, were enrolled as research subjects and divided, using the random number table, into observation group ( n = 40) receiving the treatment of Esomeprazole quadruple therapy, and control group (n = 40) receiving the treatment of Omeprazole quadruple therapy. The clinical symptom scores, Hp eradication rate, gastric mucosal blood flow ( GMBF), levels of inflammatory factors and occurrence of adverse reactions were compared between the two groups. Results After 14 days of treatment, the scores of such symptoms as burning pain in the stomach, bloating and belching, nausea and vomiting, and the levels of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in observation group were significantly lower than that in control group ( t = 2.775、4.236、4.996、6.509、9.706,P = 0.007、P < 0.001、P < 0.001、P < 0.001、P < 0.001).The Hp eradication rate in observation group was 87.50%, obviously higher than67.50%in control group(χ2 = 4.588,P = 0.032); GMBF in lesser curvature, greater curvature, anterior gastric wall and posterior gastric wall were significantly higher compared with control group (t=4.529,4.111,4.252,all P < 0.001). During the course of treatment, the incidence of adverse reactions in observation group was 10.00%, which showed no statistically significantdifference compared with 20.00% in control group(χ2 = 1.569,P = 0.210).Conclusion Compared with the Omeprazole quadruple therapy, the Esomeprazole quadruple therapy is better in restoring the gastric mucosal blood flow, inhibiting the secretion of IL-8 and TNF-α, eradicating Helicobacter pylori and alleviating patients’ clinical symptoms. |
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