| 姬 振,陈 琼,董昆仑.腹腔镜下胃穿孔修补术对老年胃穿孔患者氧化应激及胃泌素水平的影响[J].中国烧伤创疡杂志,2022,(5):377~380. |
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| 中文关键词: 胃穿孔修补术 胃穿孔 胃泌素 氧化应激 丙二醛 超氧化物歧化酶 |
| 英文关键词:Gastric perforation repair Gastric perforation Gastrin Oxidative stress Malondialdehyde Superoxide dismutase |
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| 中文摘要: |
| 【摘要】 目的 探讨腹腔镜下胃穿孔修补术对老年胃穿孔患者氧化应激及胃泌素水平的影响。方法 选取2019年8月至2020年12月淮滨县人民医院收治的75例老年胃穿孔患者作为研究对象,根据不同治疗方法将其分为腹腔镜组(40例) 和开腹组 (35例), 腹腔镜组患者采用腹腔镜下胃穿孔修补术治疗,开腹组患者采用开腹胃穿孔修补术治疗, 对比观察两组患者手术时间、术中出血量、肠鸣音恢复时间、肛门排气时间、住院时间及 氧化应激水平、胃泌素水平与疼痛程度变化情况。结果 腹腔镜组患者手术时间明显长于开腹组,术中出血量明显少于开腹组,肠鸣音恢复时间、肛门排气时间、住院时间均明显短于开腹组(t = 5.628、5.655、5.474、5.177、7.267，P 均 < 0.001）；术后1、24 h,腹腔镜组患者丙二醛(MDA)、超氧化物歧化酶(SOD)水平均明显低于开腹组(术后1 h: t=4.037、2.974，P<0.001、P=0.004；术后24 h:t=5.721、2.950，P < 0.001、P = 0.004）；术后 1、24、48、72 h,腹腔镜组患者胃泌素水平均明显高于开腹组 ( t = 2.897、2.703、3.583、3.393，P = 0.005、P = 0.009、P <0.001、P <0.001）；术后 1、3 d, 腹腔镜组患者视觉模拟评分法(VAS)评分均明显低于开腹组 (t = 2.437、2.686，P = 0.017、0.009）。结论 采用腹腔镜下胃穿孔修补术治疗老年胃穿孔, 可降低患者术后机体氧化应激反应, 提高胃泌素水平, 减轻疼痛, 缩短住院时间, 临床应用价值较高。 |
| 英文摘要: |
| 【Abstract】 Objective To study the influence of laparoscopic repair of gastric perforation on levels of serum gastrin and oxidative stress in elderly patients with gastric perforation. Methods 75 elderly patients with gastric perforation, admitted into Huaibin People’s Hospital between August 2019 and December 2020, were enrolled as research subjects, and then divided into laparoscopic group (n = 40) receiving laparoscopic repair of gastric perforation, and laparotomy group (n=35) receiving laparotomy repair of gastric perforation. The indexes, including operation time, intraoperative blood loss, bowel sound return time, anal exhaust time, length of stay, level of oxidative stress and gastrin, and pain degree of patients, were observed and compared between the two groups. Results Compared with laparotomy group, the operation time in laparoscopic group was obviously longer (t=5.628,P < 0.001),intraoperative blood loss was markedly less(t =5.655, P <0.001), and bowel sound return time, anal exhaust time and length of stay were all significantly shorter(t = 5.474、5.177 and 7.267, all P <0.001).At 1 h and 24 h after operation, the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in laparoscopic group were obviously lower than that in laparotomy group (1 h after operation: t=4.037 and 2.974,P < 0.001,P = 0.004;24 h after operation: t = 5.721 and 2.950,P < 0.001,P = 0.004).At 1 h,24 h, 48 h and 72 h after operation, the gastrin levels of patients in laparoscopic group were all significantly higher than that in laparotomy group (t = 2.897,2.703,3.583 and 3.393,P = 0.005,P = 0.009,P < 0.001,P < 0.001).On day 1 and3 after operation, the visual analogue scale (VAS) scores of patients in laparoscopic group were both lower than that in laparotomy group (t = 2.437 and 2.686,P = 0.017 and 0.009).Conclusion In the treatment of gastric perforation in elderly patients, the laparoscopic repair of gastric perforation can decrease the oxidative stress response of patients after operation, increase gastrin level, relieve patient’s pain, and shorten length of stay, presenting much high value of clinical application. |
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