| 龚 辉,席 悦.磷酸铝凝胶在儿童Hp感染性消化性溃疡中的应用效果分析[J].中国烧伤创疡杂志,2023,35(1):79~82. |
| DOI： |
| 中文关键词: 儿童 消化性溃疡 磷酸铝凝胶 幽门螺杆菌感染 奥美拉唑 阿莫西林 克拉霉素 |
| 英文关键词:Children Peptic ulcer Aluminum Phosphate Gel Helicobacter pylori infection Omeprazole Amoxicillin Clarithromycin |
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| 中文摘要: |
| 【摘要】 目的 分析磷酸铝凝胶在儿童 Hp 感染性消化性溃疡中的应用效果? 方法 选取 2020 年 1 月至2021 年 12 月南阳市中心医院收治的 76 例 Hp 感染性消化性溃疡患儿作为研究对象, 并按照不同治疗方法将其分为观察组 (38 例) 与对照组 (38 例), 对照组患儿采用奥美拉唑肠溶胶囊 + 阿莫西林胶囊 + 克拉霉素胶囊三联疗法治疗, 观察组患儿在对照组治疗的基础上联合应用磷酸铝凝胶, 对比观察两组患儿腹痛缓解时间, 反酸缓解时间, 烧灼感缓解时间, 转化生长因子-α (TGF-α)、胃泌素、前列腺素 E2 (PGE2)、表皮生长因子 (EGF) 水平变化情况以及临床疗效, Hp 转阴率与不良反应发生情况? 结果 (1) 观察组患儿腹痛缓解时间、反酸缓解时间、烧灼感缓解时间均明显短于对照组 (t =8. 449、4. 640、7. 449, P 均 <0. 001)? (2) 治疗 4 周后, 观察组患儿 TGF-α、PGE2、EGF 水平均明显高于对照组, 胃泌素水平明显低于对照组 (t = 4. 523、10. 716、9. 232、6. 202, P 均 <0. 001); 观察组患儿中治愈 34 例、有效 3 例、无效 1 例, 明显优于对照组患儿的治愈 27 例、有效4 例、无效 7 例 (Z = -2. 119, P =0. 034); 观察组患儿 Hp 转阴率为 86. 84%, 明显高于对照组患儿的 Hp 转阴率 65. 79% (χ 2 =4. 659, P =0. 031)? (3) 治疗期间, 观察组患儿不良反应发生率为 15. 79%, 与对照组患儿的不良反应发生率 13. 16%无明显差异 (χ 2 =0. 106, P =0. 744)? 结论 在奥美拉唑肠溶胶囊 + 阿莫西林胶囊 + 克拉霉素胶囊三联疗法治疗的基础上联合应用磷酸铝凝胶, 可有效调节 Hp 感染性消化性溃疡患儿 TGF-α、PGE2、EGF 及胃泌素水平, 改善患儿临床症状, 提高 Hp 转阴率, 疗效确切, 值得临床推广应用? |
| 英文摘要: |
| 【Abstract】 Objective To analyze the curative effect of Aluminum Phosphate Gel in children with Hp-induced peptic ulcer. Methods 76 children patients with Hp-induced peptic ulcers, admitted to Nanyang Central Hospital from January 2020 to December 2021, were enrolled as research subjects and divided, based on the treatments they received, into study group (n =38) and control group (n =38). The patients in control group were treated with the triple therapy of Omeprazole Enteric Coated Capsules + Amoxicillin Capsules + Clarithromycin Capsules, while the patients in study group were given the Aluminum Phosphate Gel besides the triple therapy used in control group. Abdominal pain relief time, acid regurgitation relief time, burning sensation relief time and changes in levels of transforming growth factor-α (TGF-α), gastrin, prostaglandin E2 (PGE2) and epidermal growth factor (EGF), clinical efficacy, Hp negative conversion rate andoccurrence of adverse reactions were observed and compared between the two groups. Results (1) The abdominal pain relief time, acid regurgitation relief time and burning sensation relief time of patients were significantly shorter in study group compared with control group (t =8. 449, 4. 640 and 7. 449, all P <0. 001). (2) After 4 weeks of treatment, the levels of TGF-α, PGE2 and EGF of patients were significantly higher in study group compared with control group, while the gastrin level was significantly lower than that in control group (t =4. 523, 10. 716, 9. 232 and 6. 202, all P <0. 001); 34 cases were cured, 3 cases were effective, and 1 case was ineffective in study group, being obviously better than control group with 27 cases cured, 4 cases effective, and 7 cases ineffective (Z = -2. 119, P =0. 034); the Hp negative conversion rate of patients was 86. 84% in study group, being much higher than 65. 79% in control group (χ 2 = 4. 659, P = 0. 031). (3) During the course of treatment, the incidences of adverse reactions were 15. 79% and 13. 16% respectively in study group and the control group, between which there was no statistically significant difference (χ 2 = 0. 106, P = 0. 744). Conclusion On the basis of the triple therapy of Omeprazole Enteric Coated Capsules, Amoxicillin Capsules and Clarithromycin Capsules, the application of Aluminum Phosphate Gel in children patients with Hp-induced peptic ulcer can effectively regulate the levels of TGF-α, PGE2, EGF and gastrin, improve clinical symptoms, increase Hp negative conversion rate, and realize definite curative effect, deserving to be promoted in clinical practice. |
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