| 申艺龙,张利锋,杜 凯.加味活血通脉汤在气滞血瘀型骨质疏松性腰椎骨折PVP术后的应用效果分析[J].中国烧伤创疡杂志,2023,(2):134~137. |
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| 中文关键词: 骨质疏松性腰椎骨折 气滞血瘀 经皮椎体成形术 活血通脉汤 低分子肝素钠 凝血功能 |
| 英文关键词:Osteoporotic vertebral fractures Qi stagnation and blood stasis Percutaneous vertebroplasty Huoxue Tongmai Decoction Low-molecular weight heparin sodium Coagulation function |
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| 中文摘要: |
| 【摘要】 目的 探讨加味活血通脉汤在气滞血瘀型骨质疏松性腰椎骨折经皮椎体成形术 (PVP) 后的应用效果。方法 选取 2019 年 5 月至 2021 年 5 月嵩县西关骨科医院收治的 92 例拟行 PVP 治疗的气滞血瘀型骨质疏松性腰椎骨折患者作为研究对象, 并按照随机数表法将其随机分为观察组(46例)和对照组(46例), 观察组患者PVP术后采用加味活血通脉汤联合低分子肝素钠治疗, 对照组患者 PVP 术后单纯采用低分子肝素钠治疗,对比观察两组患者凝血功能以及疼痛和深静脉血栓发生情况。结果 术后 2 周, 观察组者活化部分凝血活酶时间 (APTT)、凝血酶原时间 (PT) 均明显长于对照组 (t = 6.266? 5.192, P均< 0.001), 纤维蛋白原 (FIB) 水平、D-二聚体 (D-D) 水平及视觉模拟评分法 (VAS) 评分均明显低于对照组 ( t = 5.977、21.543、2.212, P <0.001、P < 0.001、P = 0.029); 术后, 观察组患者深静脉血栓发生率为 4.35% , 明显低于对照组患者的深静脉血栓发生率 17.39% (χ2= 4.039, P = 0.045)。结论 气滞血瘀型骨质疏松性腰椎骨折患者 PVP 术后在应用低分子肝素钠的基础上联合应用加味活血通脉汤治疗, 可明显改善患者凝血功能, 缓解患者疼痛, 降低深静脉血栓发生风险。 |
| 英文摘要: |
| 【Abstract】 Objective To study the application effect of Modified Huoxue Tongmai Decoction after the percutaneous vertebroplasty (PVP) for Qi stagnation and blood stasis type osteoporotic fracture of lumbar vertebrae. Methods 92 patients with Qi stagnation and blood stasis type osteoporotic fracture of lumbar vertebrae, admitted into Songxian Xiguan Orthopaedic Hospital from May 2019 to May 2021 for PVP operation, were enrolled as research subjects, and then divided,using the random number table, into study group (n = 46) and control group (n = 46). Patients in study group were treated with Modified Huoxue Tongmai Decoction combined with low-molecular weight heparin sodium after the PVP operation,whereas patients in control group were given the low-molecular weight heparin sodium alone after the PVP operation. The coagulation function, pain degree, and occurrence of deep vein thrombosis were compared between the two groups.Results Two weeks after the PVP operation, the activated partial thromboplastin time (APTT) and prothrombin time (PT) of patients were significantly longer in study group compared with control group ( t = 6.266 and 5.192, both P < 0.001),while the levels of fibrinogen (FIB) and D-dimer (D-D), and the score of the visual analogue scale (VAS) of patients in study group were significantly lower than that in control group (t = 5.977, 21.543 and 2.212, P < 0.001, P < 0.001, P =0.029). After the operation, the incidence of deep vein thrombosis was 4.35% in study group, much lower than 17.39% in control group (χ2= 4.039, P = 0.045). Conclusion For patients with Qi stagnation and blood stasis type osteoporotic fracture of lumbar vertebrae, the combined application of Modified Huoxue Tongmai Decoction and low-molecular weight heparin sodium after the PVP operation can significantly improve patients’ coagulation function, relieve their pain, and reduce the occurrence risk of deep vein thrombosis. |
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