| 屈盼盼,梅朝阳.益气和胃胶囊在慢性胃溃疡患者中的应用效果分析[J].中国烧伤创疡杂志,2023,(3):231~235. |
| DOI： |
| 中文关键词: 慢性胃溃疡 益气和胃胶囊 胃酸 胃黏膜屏障 肠道菌群 胃肠道生物屏障 |
| 英文关键词:Chronic gastric ulcer Yiqi Hewei Capsules Gastric acid Gastric mucosal barrier Intestinal flora Gastrointestinal biological barrier |
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| 中文摘要: |
| 【摘要】 目的 研究分析益气和胃胶囊在慢性胃溃疡患者中的应用效果。方法 选取 2020 年 3月至2020年9月郑州阳城医院收治的74例慢性胃溃疡患者作为研究对象，按照不同治疗方法将其分为观察组(37例)和对照组(37例), 对照组患者采用雷贝拉唑+阿莫西林+甲硝唑+枸橼酸铋钾+双歧杆菌四联活菌片治疗, 观察组患者在对照组治疗的基础上加用益气和胃胶囊, 对比观察两组患者临床疗效、胃功能相关指标表达水平以及肠道菌群变化情况。结果 治疗4周后, 观察组患者中显效24例、有效12例、无效1例, 明显优于对照组患者的显效 11例、有效20例、无效6例 (Z =-3.196, P=0.001); 观察组患者血清胃泌素(GAS)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、D-乳酸、二胺氧化酶(DAO)、内毒素(ET)水平均明显低于对照组 ( t =3.076、4.007、2.820、5.343、8.951、4.939, P = 0.003、P＜0.001、P = 0.006、P＜0.001、P＜0.001、P＜0.001); 观察组患者肠道内乳酸菌、双歧杆菌菌群数量均明显高于对照组 ( t = 10.384、6.845, P 均＜0.001),肠杆菌、肠球菌菌群数量均明显低于对照组 (t = 10.932、7.149, P 均＜0.001)。结论 在雷贝拉唑四联疗法辅以双歧杆菌四联活菌片治疗的基础上加用益气和胃胶囊，可有效抑制慢性胃溃疡患者胃酸分泌, 改善胃黏膜屏障功能, 调节肠道菌群平衡, 疗效显著。 |
| 英文摘要: |
| 【Abstract】 Objective To study the clinical efficacy of Yiqi Hewei Capsules (a Chinese herb preparation with the function of tonifying Qi and harmonizing stomach) in the treatment of chronic gastric ulcer. Methods 74 patients with chronic gastric ulcer admitted into Zhengzhou Yangcheng Hospital between March 2020 and September 2020 were enrolled as research subjects, and then divided into study group (n = 37) and control group (n = 37) based on different treatments they received. Patients in the control group were treated with Rabeprazole + Amoxicillin + Metronidazole + Bismuth Potassium Citrate + Tetralogy of Viable Bifidobacterium Tablets, while patients in the study group were given Yiqi Hewei Capsules besides the medicines used in the control group. The clinical efficacy, expression levels of gastric function-related indicators and changes of intestinal flora were compared between the two groups. Results After 4 weeks of treatment, the clinical efficacy was evaluated as marked effective in 24 cases, effective in 12 cases, and ineffective in 1 case in the study group, which was obviously better than that in the control group (Z = - 3.196, P = 0.001) -marked effective in 11 cases, effective in 20 cases and ineffective in 6 cases. The levels of gastrin (GAS), pepsinogen Ⅰ (PGⅠ), pepsinogenⅡ (PG Ⅱ),D-lactic acid, diamine oxidase (DAO), endotoxin (ET) of patients were all significantly higher in the study group compared with the control group (t = 3.076, 4.007, 2.820, 5.343, 8.951 and 4.939, P = 0.003, P < 0.001, P = 0.006,P < 0.001, P < 0.001, P < 0.001). The counts of gut lactic acid bacteria and bifidobacterium in the study group were obviously higher than that in the control group (t = 10.384 and 6.845, both P < 0.001), while the counts of enteric bacilli and enterococcus were obviously lower in the study group (t = 10.932 and 7.149, both P < 0.001). Conclusion On the basis of Rabeprazole-based quadruple therapy and Tetralogy of Viable Bifidobacterium Tablets, the additional application of Yiqi Hewei Capsules can effectively inhibit the secretion of gastric acid in patients with chronic gastric ulcer, improve the barrier function of gastric mucosa and regulate the balance of intestinal flora, and the clinical efficacy is definite. |
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