| 阮景艳,田园园,和娟娟.奥美拉唑三联疗法在儿童 Hp感染性消化性溃疡中的应用效果分析[J].中国烧伤创疡杂志,2023,(3):236~239. |
| DOI： |
| 中文关键词: 奥美拉唑 儿童 消化性溃疡 幽门螺杆菌 炎症因子 |
| 英文关键词:Omeprazole Children Peptic ulcer Helicobacter pylori Inflammatory factor |
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| 中文摘要: |
| 【摘要】 目的 分析奥美拉唑三联疗法在儿童幽门螺杆菌 (Hp) 感染性消化性溃疡中的应用效果。方法 选取2018年1月至2020年6月睢县妇幼保健院收治的123例Hp感染性消化性溃疡患儿作为研究对象, 按照随机数表法将其随机分为观察组(62 例)和对照组 (61 例), 观察组患儿采用奥美拉唑 + 阿莫西林 + 克拉霉素治疗, 对照组患儿采用西咪替丁 + 阿莫西林 + 克拉霉素治疗, 对比观察两组患儿临床疗效、Hp清除率、血清炎症因子水平以及不良反应发生情况。结果 治疗 4 周后, 观察组患儿中显效 48 例、有效 12 例、无效 2 例, 明显优于对照组患儿的显效 35 例、有效 16 例、无效 10 例 ( Z = - 2.595, P = 0.009); 观察组患儿 Hp 清除率为93.55% , 明显高于对照组患儿的 Hp 清除率 75.41% ( χ2= 7.745, P = 0.005); 观察组患儿血清白细胞介素-6(IL-6)、C 反应蛋白 (CRP) 和肿瘤坏死因子-α (TNF-α) 水平均明显低于对照组 ( t = 8.510、13.467、5.199,P 均 < 0.001).治疗期间, 观察组患儿不良反应发生率为 8.06% , 与对照组患儿的不良反应发生率 6.56% 无明显差异 (χ2= 0.103, P = 0.748)。结论 以奥美拉唑为主的三联疗法更能提高儿童 Hp 感染性消化性溃疡的 Hp清除率, 降低炎症反应程度, 提高治疗效果。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the curative effect of Omeprazole in the treatment of Hp-positive peptic ulcer in children patients. Methods 123 children with Hp-positive peptic ulcer admitted into Suixian Maternity and Child Health Care Hospital between January 2018 and June 2020 were enrolled as research subjects, and then divided into study group (n = 62) and control group (n = 61) using the random number table. Patients in the study group were treated with Omeprazole + Amoxicillin + Clarithromycin, while patients were treated with Cimetidine + Amoxicillin + Clarithromycin in the control group. The curative effect, Hp eradication rate, levels of inflammatory factors and occurrence of adverse reactions were compared between the two groups. Results After 4 weeks of treatment, the curative effect was evaluated as markedly effective in 48 cases, effective in 12 cases and ineffective in 2 cases in the study group, which was obviously superior to that in the control group (Z = - 2.595, P = 0.009) - markedly effective in 35 cases, effective in 16 cases andineffective in 10 cases. The Hp eradication rate of patients in the study group was 93.55% , being obviously higher than the corresponding 75.41% in the control group ( χ2= 7.745, P = 0.005). The levels of interleukin-6(IL-6), C-reactive protein (CRP) and tumor necrosis factor -α (TNF-α) of patients in the study group were all markedly lower compared with the control group (t = 8.510, 13.467 and 5.199, all P < 0.001). During the course of treatment, the incidence of adverse reactions was 8.06% in the study group, which showed no significant difference compared with the corresponding 6.56% in the control group (χ2 = 0.103, P = 0.748). Conclusion The Omeprazole-based triple therapy is more favorable for the elevation of Hp eradication rate in children patients with Hp-positive peptic ulcer, the decrease of inflammatory responses,and the improvement of curative effect. |
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