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复合溶葡萄球菌酶消毒剂联合湿润烧伤膏治疗Ⅱ度烧伤疗效分析
Clinical Efficacy of Compound Lysostaphin Disinfectant Combined with MEBO in the Treatment of Second⁃degree Burns

张燕祝,王　萌.复合溶葡萄球菌酶消毒剂联合湿润烧伤膏治疗Ⅱ度烧伤疗效分析[J].中国烧伤创疡杂志,2023,(4):266~270.

DOI：

中文关键词: Ⅱ度烧伤湿润烧伤膏复合溶葡萄球菌酶消毒剂细菌载荷量瘢痕增生

英文关键词:Second-degree burn MEBO Compound Lysostaphin Disinfectant Bacterial load Scar hyperplasia

基金项目:

作者	单位
张燕祝	471000 河南洛阳, 河南科技大学第一附属医院烧伤甲状腺外科
王　萌

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中文摘要:

【摘要】目的分析探讨复合溶葡萄球菌酶消毒剂联合湿润烧伤膏治疗Ⅱ度烧伤的临床疗效。方法选取2020 年 5 月至 2021 年 5 月河南科技大学第一附属医院收治的 64 例Ⅱ度烧伤患者作为研究对象, 按照随机数表法将其随机分为观察组 (32 例) 与对照组 (32 例), 观察组患者局部创面采用复合溶葡萄球菌酶消毒剂联合湿润烧伤膏治疗, 对照组患者局部创面采用复合溶葡萄球菌酶消毒剂联合凡士林水胶体敷贴治疗, 对比观察两组患者创面细菌培养情况、血清炎症因子水平、创面疼痛评分、创面愈合率与愈合时间以及愈后皮肤瘢痕增生情况。结果治疗3 d 后, 观察组患者创面铜绿假单胞菌、鲍曼不动杆菌、大肠杆菌的细菌载荷量均明显低于对照组 (t =123.030、270.124、4.475, P 均 <0.001); 治疗第 14 天, 观察组患者肿瘤坏死因子-α (TNF-α)、白细胞介素-10(IL-10) 水平均明显低于对照组 (t =5.573、2.468, P <0.001、P =0.016); 治疗第 7、14 天, 观察组患者创面视觉模拟评分法 (VAS) 评分均明显低于对照组 (t =6.236、4.389, P 均 <0.001)、创面愈合率均明显高于对照组 (t =3.617、5.304, P 均 <0.001); 观察组患者创面愈合时间明显短于对照组 (t =3.545, P <0.001); 观察组患者愈后皮肤温哥华瘢痕量表 (VSS) 中色泽、血管分布、厚度、柔软度评分均明显低于对照组 (t = 3.607、2.281、3.194、3.737, P <0.001、P =0.026、P =0.002、P =0.001)。结论复合溶葡萄球菌酶消毒剂联合湿润烧伤膏能够有效降低Ⅱ度烧伤患者创面细菌载荷量、炎症反应及疼痛程度, 缩短创面愈合时间, 减轻瘢痕增生。

英文摘要:

【Abstract】 Objective To analyze the clinical efficacy of Compound Lysostaphin Disinfectant combined with MEBO in the treatment of second-degree burns. Methods 64 patients with second-degree burns admitted into The First Affiliated Hospital of Henan University of Science and Technology between May 2020 and May 2021 were enrolled as research subjects, and divided into study group (n =32) and control group (n =32) using the random number table. The local wounds of patients were treated with Compound Lysostaphin Disinfectant combined with MEBO in the study group, while the local wounds of patients in the control group were treated with Compound Lysostaphin Disinfectant combined with Vaseline Hydrocolloid Dressing. The bacterial culture results, levels of serum inflammatory factors, wound pain score, wound healing rate and healing time, and scar hyperplasia of healed skin of patients were compared between the two groups.Results After three days of treatment, the loads of pseudomonas aeruginosa, acinetobacter baumannii and E. coli in burn wounds of patients were obviously lower in the study group compared with the control group (t = 123. 030, 270. 124 and 4. 475, all P <0. 001). On day 14 of treatment, the levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) of patients in the study group were obviously lower than that in the control group (t =5. 573 and 2. 468, P <0. 001, P = 0. 016). Respectively on day 7 and 14 of treatment, the visual analogue scale (VAS) scores of patients were markedly lower in the study group compared with the control group (t =6. 236 and 4. 389, both P <0. 001), and the wound healing rates were obviously higher in the study group (t =3. 617 and 5. 304, both P <0. 001). The would healing time of patients in the study group was significantly shorter than that in the control group (t =3. 545, P <0. 001). The Vancouver scar scale (VSS) scores of healed skin in terms of pigmentation, vascularity, height and pliability in the study group were all significantly lower than that in the control group (t =3. 607, 2. 281, 3. 194 and 3. 737, P <0. 001, P =0. 026, P =0. 002, P =0. 001). Conclusion The combined application of Compound Lysostaphin Disinfectant and MEBO can effectively reduce the bacterial loads in wounds of patients with second-degree burns, decrease their inflammatory responses and pain, shorten wound healing time and alleviate scar hyperplasia.