| 马 智,李 昶,曹 男.醋酸奥曲肽不同给药方式治疗胃溃疡合并失血性休克疗效对比[J].中国烧伤创疡杂志,2023,(4):321~324. |
| DOI： |
| 中文关键词: 皮下注射 持续静脉泵注 埃索美拉唑 醋酸奥曲肽 胃溃疡 失血性休克 |
| 英文关键词:Subcutaneous injection Continuous intravenous pumping Esomeprazole Octreotide Acetate Gastric ulcer Hemorrhagic shock |
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| 中文摘要: |
| 【摘要】 目的 对比分析醋酸奥曲肽不同给药方式治疗胃溃疡合并失血性休克的临床效果。 方法 选取2019年7月至2021年7月辽宁省人民医院收治的 90 例胃溃疡合并失血性休克患者作为研究对象, 按照不同给药方式将其分为观察组 (45 例) 和对照组 (45 例), 观察组患者予以静脉滴注注射用埃索美拉唑钠联合皮下注射注射用醋酸奥曲肽治疗, 对照组患者予以静脉滴注注射用埃索美拉唑钠联合持续静脉泵注注射用醋酸奥曲肽治疗, 对比观察两组患者血红蛋白水平、胃液 pH 值、止血时间、输血量与不良反应发生情况。结果 治疗 14 d后, 观察组患者血红蛋白水平与胃液 pH 值均明显高于对照组 (t =6.037、14.956, P 均 <0.001)。观察组患者止血时间及输血量与对照组无明显差异 (t =0.445、0.373, P =0.657、0.710)。治疗期间, 观察组患者不良反应发生率为 6.67%, 与对照组患者的不良反应发生率 11.11%无明显差异 (χ 2 =0.549, P =0.459)。 结论 皮下注射与持续静脉泵注注射用醋酸奥曲肽治疗胃溃疡合并失血性休克的止血效果虽相当, 但皮下注射更有利于提高血红蛋白水平与胃液 pH 值。 |
| 英文摘要: |
| 【Abstract】 Objective To compare the curative effect of Octreotide Acetate in different delivery methods in the treatment of gastric ulcer complicated with hemorrhagic shock. Methods 90 patients with gastric ulcer and hemorrhagic shock admitted into The People’s Hospital of Liaoning Province between July 2019 and July 2021 were enrolled as research subjects, and divided into study group (n = 45) and control group (n = 45) based on different delivery methods they received. Patients in the study group were treated with intravenous infusion of Esomeprazole Sodium for Injection plus subcutaneous injection of Octreotide Acetate for Injection, while patients were treated with intravenous infusion of Esomeprazole Sodium for Injection plus continuous intravenous pumping of Octreotide Acetate for Injection in the control group. The level of hemoglobin, pH value of gastric juice, hemostasis time, transfusion volume and occurrence of adverse reactions of patients were compared between the two groups. Results After 14 days of treatment, the level of hemoglobin and pH value of gastric juice of patients were both obviously higher in the study group compared with the control group (t = 6.037 and 14.956, both P <0.001). There was no statistically significant difference between the two groups in terms of hemostasis time and transfusion volume of patients (t =0.445 and 0.373, P =0.657 and 0.710). During the course of treatment, the incidence of adverse reactions of patients in the study group was 6.67%, showing no statistically significant difference compared with the corresponding 11.11% in the control group (χ 2 =0.549, P =0.459). Conclusion Though subcutaneous injection and continuous intravenous pumping of Octreotide Acetate for Injection can realize the equivalent hemostatic effect in patients with gastric ulcer complicated with hemorrhagic shock, the subcutaneous injection is more favorable for elevating the level of hemoglobin and pH value of gastric juice. |
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