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湿润烧伤膏保留灌肠治疗放射性肠炎疗效分析
Clinical Efficacy of MEBO Retention Enema in the Treatment of Radiation Enteritis

袁丹,王贵华,吴慧,何琴.湿润烧伤膏保留灌肠治疗放射性肠炎疗效分析[J].中国烧伤创疡杂志,2023,(5):337~339.

DOI：

英文关键词:MEBO Radiation enteritis Radioactive therapy Inflammatory response Inflammatory factor

基金项目:株洲市创新型城市建设专项社会化出资项目 (21019)

作者	单位
袁丹	412005 湖南株洲, 株洲市二医院肿瘤一科
王贵华
吴慧
何琴

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中文摘要:

【摘要】目的分析探讨湿润烧伤膏保留灌肠治疗放射性肠炎的临床疗效。方法选取2019年1月至2022年1月株洲市二医院收治的68例放射性肠炎患者作为研究对象,按照随机数表法将其随机分为试验组(34例)与对照组(34例),试验组患者予以湿润烧伤膏保留灌肠治疗,对照组患者予以硫酸庆大霉素注射液+地塞米松磷酸钠注射液+0.9%氯化钠注射液保留灌肠治疗,对比观察两组患者治疗期间血清炎症因子水平变化情况以及临床疗效。结果治疗第7、14天,试验组患者血清白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hs-CRP)水平均明显低于对照组(治疗第7天:t=14.609、9.718、14.732、10.195,P均<0.001;治疗第14天:t=29.312、16.069、13.450、14.619,P均<0.001)?治疗3周后,试验组患者治愈28例、有效3例、无效3例,明显优于对照组患者的治愈21例、有效2例、无效11例(Z=-2.069,P=0.039)。结论湿润烧伤膏保留灌肠可明显改善放射性肠炎患者机体炎症反应程度,提高治疗效果。

英文摘要:

【Abstract】 Objective To analyze the clinical efficacy of MEBO retention enema in the treatment of radiation enteritis. Methods 68 patients with radiation enteritis admitted into Zhuzhou Second Hospital between January 2019 and January 2022 were enrolled as research subjects, and divided into study group (n = 34) and control group ( n = 34) using the random number table. Patients in the study group were treated with MEBO retention enema, while patients were treated with the retention enema of Gentamycin Sulfate Injection + Dexamethasone Sodium Phosphate Injection + 0.9% Sodium Chloride Injection in the control group. The changes of serum inflammatory factors during the course of treatment and clinical efficacy were compared between the two groups. Results Respectively on day 7 and 14 of treatment, the levels of serum interleukin (IL) -6, IL-8, tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein ( hs-CRP) of patients were all significantly lower in the study group compared with the control group ( day 7 of treatment: t = 14.609, 9.718, 14.732 and 10.195, all P < 0.001; day 14 of treatment: t = 29.312, 16.069, 13.450 and 14.619, all P < 0.001). After three weeks of treatment, 28 cases were cured, 3 cases showed effective and 3 cases were ineffective in the study group,being obviously better than that in the control group (Z = - 2.069, P = 0.039) - 21 cured, 2 effective and 11 ineffective.Conclusion MEBO retention enema can significantly ameliorate the inflammatory responses of patients with radiation enteritis and improve the therapeutic effect.