• 奥美拉唑三联疗法联合中药穴位贴敷治疗脾胃虚寒型胃溃疡疗效分析
  • Clinical Efficacy of Omeprazole Triple Therapy Combined with Chinese Medicine Acupoint Application in the Treatment of Gastric Ulcer of Spleen and Stomach Deficiency-cold Syndrome
  • 吕传芳,赵 燕,张家家.奥美拉唑三联疗法联合中药穴位贴敷治疗脾胃虚寒型胃溃疡疗效分析[J].中国烧伤创疡杂志,2023,(6):483~487.
    DOI:
    中文关键词:  中药  穴位贴敷  奥美拉唑三联疗法  脾胃虚寒  胃溃疡  胃肠激素  炎症反应
    英文关键词:Chinese medicine  Acupoint application  Omeprazole triple therapy  Spleen and stomach deficiency-cold syndrome  Gastric ulcer  Gastrointestinal hormone  Inflammatory response
    基金项目:
    作者单位
    吕传芳 464000 河南 信阳, 信阳市平桥区中医院中西医结合内科 
    赵 燕  
    张家家  
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    中文摘要:
          【摘要】 目的 探讨奥美拉唑三联疗法联合中药穴位贴敷治疗脾胃虚寒型胃溃疡的临床疗效。 方法 选取2020 年 1 月至 2022 年 1 月信阳市平桥区中医院收治的 80 例脾胃虚寒型胃溃疡患者作为研究对象, 按照不同治疗方法将其分为观察组 (40 例) 和对照组 (40 例), 观察组患者采用奥美拉唑三联疗法联合中药穴位贴敷治疗,对照组患者单纯采用奥美拉唑三联疗法治疗, 对比观察两组患者血清胃肠激素及炎症因子水平、中医症状积分?临床疗效以及不良反应发生情况。 结果 治疗 2 个月后, 观察组患者血清胃动素 (MOT)、胃泌素 (GAS)、白细胞介素 (IL) -6、IL-8、肿瘤坏死因子-α (TNF-α) 水平以及腹痛、腹胀、反酸嗳气评分均明显低于对照组 ( t =6.407、4.948、11.432、8.875、13.345、2.656、3.134、3.251, P < 0.001、P < 0.001、P < 0.001、P < 0.001?P < 0.001、P = 0.010、P = 0.002、P = 0.002), 临床疗效明显优于对照组 (Z = - 1.976, P = 0.048)。 治疗期间,观察组患者不良反应发生率为 7.50% , 与对照组患者的不良反应发生率 12.50% 无明显差异 ( χ2= 0.556, P =0.456)。 结论 在奥美拉唑三联疗法治疗的基础上联合应用中药穴位贴敷治疗脾胃虚寒型胃溃疡, 可明显改善胃肠激素水平, 减轻炎症反应程度, 缓解临床症状, 提高治疗效果, 安全性较高。
    英文摘要:
          【Abstract】 Objective To study the clinical efficacy of Omeprazole triple therapy combined with Chinese medicine acupoint application in the treatment of gastric ulcer of spleen and stomach deficiency-cold syndrome. Methods 80 patients with gastric ulcer of spleen and stomach deficiency-cold syndrome, admitted to Xinyang Pingqiao District Hospital of Traditional Chinese Medicine from January 2020 to January 2022, were enrolled as research subjects and divided, based on the treatments they received, into study group ( n = 40) and control group ( n = 40). Patients in the study group were treated with Omeprazole triple therapy combined with Chinese medicine acupoint application, while patients in the control group were treated with Omeprazole triple therapy alone. The levels of serum gastrointestinal hormones and inflammatoryfactors, TCM syndrome scores, clinical efficacy and occurrence of adverse reactions of patients were compared between the two groups. Results After two months of treatment, as compared with the control group, the levels of serum motilin(MOT), gastrin (GAS), interleukin (IL) -6, IL-8, tumor necrosis factor-α (TNF-α) and the scores of abdominal pain, abdominal distension, acid regurgitation and belching of patients in the study group were all significantly lower (t = 6.407,4.948, 11.432, 8.875, 13.345, 2.656, 3.134 and 3.251, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P = 0.010, P = 0.002, P = 0.002), and the clinical efficacy was obviously better in the study group (Z = - 1.976, P = 0.048). During the course of treatment, the incidence of adverse reactions of patients was 7.50% in the study group, which showed no significant difference compared with the corresponding 12.50% in the control group (χ2= 0.556, P =0.456). Conclusion The combined application of Chinese medicine acupoint application on the basis of the Omeprazole triple therapy in the treatment of gastric ulcer of spleen and stomach deficiency-cold syndrome can effectively improve the levels of gastrointestinal hormones, reduce inflammatory response, alleviate clinical symptoms, and achieve good clinical efficacy with high safety.