| 蔡华岭,周雅兰,张冬利,张金生,潘 丹.康复新液在幽门螺杆菌感染性胃溃疡中的应用效果分析[J].中国烧伤创疡杂志,2023,(6):488~491. |
| DOI： |
| 中文关键词: 康复新液 泮托拉唑 胃溃疡 炎症因子 免疫功能 |
| 英文关键词:Kangfuxin Solution Pantoprazole Gastric ulcers Inflammatory factors Immune function |
| 基金项目: |
|
| 摘要点击次数: 1256 |
| 全文下载次数: 3820 |
| 中文摘要: |
| 【摘要】 目的 探讨分析康复新液在幽门螺杆菌感染性胃溃疡中的应用效果。方法 选取 2021 年 1 月至2022 年 1 月确山县人民医院收治的 89 例幽门螺杆菌感染性胃溃疡患者作为研究对象, 并按照随机数表法将其随机分为观察组 (45 例) 和对照组 (44 例)。 观察组患者采用康复新液联合泮托拉唑治疗, 对照组患者单纯采用泮托拉唑治疗, 对比观察两组患者血清炎症因子及免疫相关指标水平、临床疗效与不良反应发生情况。 结果 治疗 14 d 后, 观察组患者血清 C 反应蛋白 (CRP)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α) 水平均明显低于对照组 (t = 3.889、4.223、3.541, P 均 < 0.001), CD3+、CD4+、CD4+/ CD8+ 水平均明显高于对照组 (t =3.689、3.461、4.364, P 均 < 0.001); 观察组患者临床疗效为优 15 例、良 22 例、可 4 例、差 4 例, 明显优于对照组患者的临床疗效为优 10 例、良 13 例、可 10 例、差 11 例 (Z = - 2.462, P = 0.014)。 治疗期间, 观察组患者不良反应发生率为 8.89% , 与对照组患者的不良反应发生率 11.36% 无明显差异 ( χ2= 0.150, P = 0.699)。 结论 在口服泮托拉唑的基础上联合应用康复新液治疗幽门螺杆菌感染性胃溃疡, 可有效提高患者免疫功能, 降低炎症反应水平, 促进溃疡创面愈合, 疗效显著。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the application effect of Kangfuxin Solution in the treatment of Helicobacter pylori-infected gastric ulcers. Methods 89 patients with Helicobacter pylori-infected gastric ulcers, admitted to People’s Hospital of Queshan from January 2021 to January 2022, were enrolled as research subjects and divided, using the random number table, into study group (n = 45) and control group (n = 44). Patients in the study group were treated with Kangfuxin Solution in combination with pantoprazole, while patients in the control group received pantoprazole alone. The levels of serum inflammatory factors and immune-related indicators, clinical efficacy, and adverse reaction occurrence were compared between the two groups. Results After 14 days of treatment, the levels of serum C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) of patients in the study group were all significantly lower than that in the control group (t = 3.889, 4.223 and 3.541, all P < 0.001), and the levels of CD3+, CD4+, and the CD4+/ CD8+ ratio were significantly higher in the study group (t = 3.689, 3.461 and 4.364, all P < 0.001). In the study group, the clinicalefficacy was evaluated as excellent in 15 cases, good in 22 cases, fair in 4 cases, and poor in 4 cases, which was significantly better than that in the control group (Z = - 2.462, P = 0.014) - excellent in 10 cases, good in 13 cases, fair in 10 cases, and poor in 11 cases. During the course of treatment, the incidence of adverse reactions was 8.89% in the study group, which showed no significant difference as compared with 11.36% in the control group (χ2= 0.150, P = 0.699). Conclusion Combining Kangfuxin Solution with oral administration of pantoprazole in the treatment of Helicobacter pylori-infected gastric ulcers can effectively enhance patients’immune functions, reduce the level of inflammatory response, and promote the healing of ulcers, and the clinical efficacy is definite. |
|
|
|
|
