| 周雅兰,蔡华岭,张冬利,潘 丹,王瑞生.康复新液在 Hp 感染性胃溃疡中的应用效果分析[J].中国烧伤创疡杂志,2024,(1):66~69. |
| DOI： |
| 中文关键词: 康复新液 幽门螺杆菌 胃溃疡 奥美拉唑四联疗法 炎症因子 胃肠激素 |
| 英文关键词:Kangfuxin Solution Helicobacter pylori Gastric ulcers Omeprazole-based quadruple therapy Inflammatory factors Gastrointestinal hormones |
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| 中文摘要: |
| 【摘要】 目的 分析探讨康复新液在幽门螺杆菌 (Hp) 感染性胃溃疡中的应用效果。方法 选取2021年1月至2022年1月确山县人民医院收治的62例Hp感染性胃溃疡患者作为研究对象,按照不同治疗方法将其分为观察组(31例) 与对照组(31 例), 对照组患者采用奥美拉唑四联疗法治疗, 观察组患者在奥美拉唑四联疗法治疗的基础上联合应用康复新液, 对比观察两组患者血清炎症因子及胃肠激素水平、临床疗效、Hp 转阴率及复阳率。结果 治疗 4 周后, 观察组患者血清白细胞介素-6 (IL-6)、胃泌素 (GAS)、胃动素 (MOT) 水平均明显低于对照组 (t = 9.153、13.644、18.528, P 均<0.001); 观察组患者痊愈 16 例、显效 7 例、有效 6 例、无效 2例, 明显优于对照组患者的痊愈10例、显效5例、有效7例、无效 9 例 (Z = -2.206, P = 0.027); 观察组患者Hp 转阴率为74.19%, 明显高于对照组患者的 Hp 转阴率 48.39% (χ2 = 4.351, P = 0.037)。治疗结束后3个月,观察组患者 Hp 复阳率为 8.70%, 明显低于对照组患者的 Hp 复阳率 40.00% (χ2 = 5.353, P = 0.021)。结论 在奥美拉唑四联疗法基础上联合应用康复新液治疗 Hp 感染性胃溃疡, 可有效降低炎症因子水平, 改善胃肠激素水平, 提高 Hp 转阴率, 降低Hp复阳率, 疗效显著。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the application effect of Kangfuxin Solution in the treatment of Helicobacter pylori (Hp)-infected gastric ulcers. Methods 62 patients with Hp-infected gastric ulcers, admitted to People’s Hospital of Queshan from January 2021 to January 2022, were enrolled as research subjects and divided into study group ( n = 31) and control group (n = 31) according to the different treatments they received. Patients in the control group were treated with omeprazole-based quadruple therapy, while patients in the study group received omeprazole-based quadruple therapy in combination with Kangfuxin Solution. The levels of serum inflammatory factors and gastrointestinal hormones, clinical efficacy, Hp negative conversion and re-positive rate of patients were compared between the two groups. Results After 4 weeks of treatment, the levels of interleukin-6 ( IL-6), gastrin (GAS) and motilin ( MOT) of patients in the study group were significantly lower than those in the control group (t = 9.153, 13.644 and 18.528, all P<0.001); 16 patients were cured,7 patients were markedly effective, 6 patients were effective, and 2 patients were ineffective in the study group, much better than that in the control group ( Z = - 2.206, P = 0.027) - 10 patients cured, 5 patients markedly effective, 7 patientseffective, and 9 patients ineffective. The Hp negative conversion rate of patients in the study group was 74.19%, which was obviously higher than the corresponding 48.39% in the control group (χ2 = 4.351, P= 0.037). Three months after the end of treatment, the re-positive rate of patients in the study group was 8.70%, significantly lower than the 40.00% in the control group (χ2 = 5.353, P= 0.021). Conclusion Combining Kangfuxin Solution with omeprazole-based quadruple therapy in the treatment of Hp-infected gastric ulcers can effectively reduce the levels of inflammatory factors and Hp re-positive rate, improve gastrointestinal hormone level, enhance Hp negative conversion rate, and the clinical efficacy is definite. |
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