| 农丝洁,代平平,郑爱甜,覃晓洁,吴标良.糖尿病足患者甲状腺功能状态及其影响因素分析[J].中国烧伤创疡杂志,2024,(4):259~263. |
| DOI： |
| 中文关键词: 糖尿病足 2型糖尿病 甲状腺功能 甘油三酯 糖化血红蛋白 |
| 英文关键词:Diabetic foot Type Ⅱ diabetes mellitus Thyroid function Triglycerides Glycated hemoglobin |
| 基金项目:广西自然科学基金重点项目 (2023GXNSFDA026008); 广西医疗卫生适宜技术开发与推广应用项目( S2022134); 广西壮族自治区中医药管理局科研项目 (GXZYZ20210525? GZZC2020255); 广西壮族自治区卫生健康委西医类别科研课题 (20210234)广西自然科学基金重点项目 (2023GXNSFDA026008); 广西医疗卫生适宜技术开发与推广应用项目( S2022134); 广西壮族自治区中医药管理局科研项目 (GXZYZ20210525? GZZC2020255); 广西壮族自治区卫生健康委西医类别科研课题 (20210234) |
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| 中文摘要: |
| 【摘要】 目的 分析探讨糖尿病足患者甲状腺功能状态及其甲状腺功能异常的危险因素。方法 选取 2016年 1 月至 2023 年 6 月右江民族医学院附属医院收治的 110 例糖尿病足患者作为研究对象, 收集患者性别、年龄、体重指数等一般资料以及入院时白细胞计数、 白蛋白、肌酐、甘油三酯、总胆固醇、空腹血糖、 糖化血红蛋白、总三碘甲状腺原氨酸 (TT3)、 总甲状腺素 (TT4)、 游离三碘甲状腺原氨酸 (FT3)、游离甲状腺素 (FT4)、促甲状腺激素 (TSH) 水平等资料, 按照 Wagner 分级将患者分为 W1 组 ( Wagner 1 级和 Wagner 2 级)、 W2 组(Wagner 3级) 和 W3 组 (Wagner 4级和 Wagner 5级), 同时根据患者是否存在甲状腺功能异常将其分为发生组和未发生组, 分析不同 Wagner 分级糖尿病足患者甲状腺功能状态及糖尿病足患者甲状腺功能异常的相关危险因素。结果 110 例糖尿病足患者甲状腺功能异常 80 例 ( 72.73%), 设为发生组; 甲状腺功能正常 30 例(27.27%), 设为未发生组。糖尿病足患者随着 Wagner 分级的升高, TT3、TT4、FT3 水平逐渐降低 (F/ H= 5.742、7.224、10.634, P = 0.004、0.001、0.005), 且 W3 组患者TT3、TT4、 FT3水平均明显低于 W1 组和 W2 组(TT3: q = 4.710、3.603, P= 0.003、0.033; TT4: q = 5.036、2.081, P= 0.044、 0.002; FT3: Z = 3.174、2.719,P= 0.005、0.020), 而 FT4、TSH 水平 3 组间无明显差异 (H= 0.147、 0.060, P= 0.929、0.970)。多因素 Logistic回归分析结果显示, 甘油三酯、 糖化血红蛋白水平较高是糖尿病足患者甲状腺功能异常的独立危险因素 (95%CI为 1.032~ 4.913、 1.012~ 1.589, P= 0.041、 0.039)。结论 甲状腺功能与糖尿病足病变程度密切相关, 且甘油三酯与糖化血红蛋白水平较高是糖尿病足患者甲状腺功能异常的独立危险因素。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the thyroid function status of patients with diabetic foot and risk factors for such patients to develop thyroid functional abnormities. Methods 110 patients with diabetic foot, admitted to the Affiliated Hospital of Youjiang Medical University for Nationalities from January 2016 to June 2023, were selected as research subjects. Their data were collected, including general data such as sex, age, and body mass index, along with data on admission such as white blood cell count, albumin, creatinine, triglycerides, total cholesterol, fasting blood glucose, glycated hemoglobin, total triiodothyronine ( TT3), total thyroxine ( TT4), free triiodothyronine ( FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels. Patients were divided into W1 group (Wagner grades 1 and 2), W2 group (Wagner grade 3), and W3 group (Wagner grades 4 and 5) based on the Wagner classification, and divided into the occurrence group and non-occurrence group according to whether they had complicated with abnormal thyroid functions, to analyze the thyroid function status of patients with diabetic foot at different Wagner severities, and the risk factors of such patients developing abnormal thyroid function. Results Among the 110 diabetic foot patients, 80 cases (72.73%) were complicated with abnormal thyroid function, being set as the occurrence group, and the other 30 cases ( 27.27%) had normal thyroid function, being set as the non-occurrence group. As the Wagner grading level increased, the TT3, TT4, and FT3 levels of patients decreased gradually (F/ H = 5.742, 7.224 and 10.634, P = 0.004, 0.001 and 0.005), and TT3, TT4, and FT3 levels in W3 group were all significantly lower than those in W1 and W2 group (TT3: q = 4.710 and 3.603, P= 0.003 and 0.033; TT4: q = 5.036 and 2.081, P = 0.044 and 0.002; FT3: Z = 3.174 and 2.719, P = 0.005 and 0.020). Although FT4 and TSH levels also decreased gradually, there were no significant differences among the three groups (H = 0.147 and 0.060, P = 0.929 and 0.970). Multivariate Logistic regression analysis indicated that higher triglyceride and HbA1c levels were independent risk factors for abnormal thyroid function in diabetic foot patients (95%CI: 1.032-4.913, 1.012-1.589, P= 0.041 and 0.039). Conclusion Thyroid function is closely related to the severity of diabetic foot, and higher triglyceride and glycated hemoglobin levels are independent risk factors for diabetic foot patients complicating with abnormal thyroid function. |
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