| 刘玉凤,刘小丽,王瑞华.补阳还五汤加减治疗气虚血瘀型糖尿病足效果分析[J].中国烧伤创疡杂志,2024,(6):429~433. |
| DOI： |
| 中文关键词: 补阳还五汤 腰交感神经毁损术 糖尿病足 血液流变学 下肢供血 |
| 英文关键词:Buyang Huanwu decoction Lumbar sympathetic nerve lesion Diabetic foot Hemorheology Lower limb blood supply |
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| 中文摘要: |
| 【摘要】 目的 分析补阳还五汤加减治疗气虚血瘀型糖尿病足的临床效果。方法 选取 2020 年11月至2022年11月项城市中医院收治的82例气虚血瘀型糖尿病足患者作为研究对象, 按照是否应用补阳还五汤加减将其分为观察组(41例)与对照组(41例),观察组患者在腰交感神经毁损术治疗基础上联合应用补阳还五汤加减，对照组患者单纯行腰交感神经毁损术治疗, 对比观察两组患者中医证候积分、血液流变学状态、疼痛情况、下肢供血情况与生活质量。结果 治疗 6 周后, 观察组患者肢体症状、局部皮肤、精神神志、舌脉积分均明显低于对照组 (t = 4.111、5.122、4.339、4.913, P 均<0.001), 全血高切黏度、全血低切黏度、血浆黏度、红细胞聚集指数以及疼痛评分亦均明显低于对照组( t = 2.999、3.309、5.588、7.532、4.613, P = 0.004、P = 0.001?P<0.001、P<0.001、P<0.001)，踝肱指数 (ABI)、2型糖尿病患者生活质量评定量表(DMQLS)评分均明显高于对照组(t = 2.316、5.248, P= 0.023、P<0.001)。结论 与单纯应用腰交感神经毁损术治疗相比，在腰交感神经毁损术基础上联合应用补阳还五汤加减治疗糖尿病足，更能显著改善患者血液流变学状态及下肢供血情况，减轻疼痛等症状，提高其生活质量。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the clinical effect of modified Buyang Huanwu decoction in the treatment of diabetic foot of Qi deficiency and blood stasis type. Methods 82 patients with diabetic foot of Qi deficiency and blood stasis type admitted to Xiangcheng Hospital of Traditional Chinese Medicine from November 2020 to November 2022 were enrolled那边as the research subjects and divided into the study group ( n = 41) and the control group ( n = 41). Patients in the study group were treated with modified Buyang Huanwu decoction in addition to lumbar sympathetic nerve lesion, whereas patients were treated with lumbar sympathetic nerve lesion alone in the control group. The TCM syndrome score, hemorheological status, pain degree, lower limb blood supply and quality of life were compared between the two groups. Results After 6 weeks of treatment, the scores of limb symptoms, local skin, mental status and tongue pulse were significantly lower in the study group compared with the control group (t = 4.111, 5.122, 4.339 and 4.913, all P<0.001), and the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, erythrocyte aggregation index and pain score werealso significantly lower in the study group (t = 2.999, 3.309, 5.588, 7.532 and 4.613, P= 0.004, P= 0.001, P<0.001, P<0.001, P<0.001), but the ankle brachial index (ABI) and quality of life scale for patients with type 2 diabetes mellitus (DMQLS) scores were significantly higher in the study group (t = 2.316 and 5.248, P= 0.023, P<0.001). Conclusion Compared with the simple application of lumbar sympathetic nerve lesion, the additional application of Buyang Huanwu decoction in the treatment of diabetic foot can significantly improve the hemorheological status and lower limb blood supply, ameliorate patients’ pain and other symptoms, and improve their quality of life. |
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