| 张承钗,陈 娟,黄 咏,许益云.三碘甲状腺原氨酸、皮质醇、免疫球蛋白 E在烧伤患者病情及预后评估中的应用[J].中国烧伤创疡杂志,2024,(6):442~446. |
| DOI： |
| 中文关键词: 三碘甲状腺原氨酸 皮质醇 免疫球蛋白E 烧伤 预后 相关性 |
| 英文关键词:Triiodothyronine Cortisol Immunoglobulin E Burns Prognosis Correlation |
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| 中文摘要: |
| 【摘要】 目的 探讨三碘甲状腺原氨酸、皮质醇、免疫球蛋白 E 在烧伤患者病情及预后评估中的应用价值。方法 选取 2022 年 1 月至 2023 年 9 月福鼎市医院收治的 150 例烧伤患者 (设为研究组), 以及同期于福鼎市医院接受体检的 58 名健康体检者 (设为对照组) 作为研究对象, 并根据患者病情严重程度及预后将研究组患者分为轻度亚组、中度亚组与重度亚组及预后良好亚组与预后不良亚组, 分析烧伤患者与健康体检者以及不同严重程度与预后的烧伤患者三碘甲状腺原氨酸、皮质醇、免疫球蛋白E水平以及三碘甲状腺原氨酸、皮质醇、免疫球蛋白 E 与烧伤患者预后的相关性。结果 研究组研究对象三碘甲状腺原氨酸水平明显低于对照组 ( t = 21.171,P<0.001), 皮质醇、免疫球蛋白E水平明显高于对照组 ( t = 136.702、13.472, P 均<0.001)。重度亚组患者三碘甲状腺原氨酸水平明显低于中度亚组与轻度亚组 (q = 22.112、54.410, P 均<0.001), 且中度亚组患者三碘甲状腺原氨酸水平明显低于轻度亚组 (q = 36.631, P<0.001); 重度亚组患者皮质醇、免疫球蛋白E水平明显高于中度亚组与轻度亚组 (皮质醇: q = 93.329、34.983, P 均< 0.001；免疫球蛋白 E: q = 12.671、6.687, P 均<0.001), 且中度亚组患者皮质醇、免疫球蛋白E水平明显高于轻度亚组 ( q = 59.961、6.607, P 均<0.001)。预后不良亚组患者三碘甲状腺原氨酸水平明显低于预后良好亚组 ( t = 27.723, P<0.001), 皮质醇、免疫球蛋白E水平明显高于预后良好亚组 (t = 19.324、3.277, P<0.001, P = 0.001)。Spearman 相关性分析结果显示, 三碘甲状腺原氨酸与烧伤患者预后呈正相关性 (r = 1.872, P<0.001), 皮质醇、免疫球蛋白E与烧伤患者预后呈负相关性 (r = -0.902、-0.876, P 均<0.001)。结论 三碘甲状腺原氨酸、皮质醇、免疫球蛋白 E 均可作为早期评估烧伤患者病情严重程度及预后的生物学指标进行临床推广。 |
| 英文摘要: |
| 【Abstract】 Objective To study the application value of triiodothyronine, cortisol and immunoglobulin E in the evaluation of disease condition and prognosis of burn patients. Methods 150 burn patients (study group) and 58 healthy subjects (control group) undergoing physical health check in Fuding Hospital between January 2022 and September 2023 were selected as the research subjects. According to the disease severity and prognosis, the patients in the study group were divided into mild subgroup, moderate subgroup, severe subgroup, good prognosis subgroup and poor prognosis subgroup. The levels of triiodothyronine, cortisol and immunoglobulin E were analyzed in burn patients and healthy subjects, as well asin burn patients with different severity and prognosis, and also the correlation of triiodothyronine, cortisol, immunoglobulin E with the prognosis of burn patients were studied. Results The triiodothyronine level in the study group was significantly lower than that in the control group (t = 21.171, P<0.001), and the levels of cortisol and immunoglobulin E were significantly higher in the study group (t = 136.702 and 13.472, both P<0.001). Patients in the severe subgroup had significantly lower levels of triiodothyronine respectively compared with patients in the moderate subgroup and the mild subgroup ( q =22.112 and 54.410, both P<0.001), and patients in the moderate subgroup had significantly lower levels of triiodothyronine than patients in the mild subgroup ( q = 36.631, P<0.001); patients in the severe subgroup had significantly higher levels of cortisol and immunoglobulin E respectively compared with patients in the moderate subgroup and the mild subgroup (cortisol: q = 93.329 and 34.983, both P< 0.001; immunoglobulin E: q = 12.671 and 6.687, both P< 0.001), and cortisol and immunoglobulin E levels of patients in the moderate subgroup were significantly higher than those in the mild subgroup (q = 59.961 and 6.607, both P<0.001). Patients in the poor prognosis subgroup had significantly lower levels of triiodothyronine than patients in the good prognosis subgroup (t = 27.723, P<0.001), and patients had significantly higherlevels of cortisol and immunoglobulin E in the poor prognosis subgroup (t = 19.324 and 3.277, P<0.001, P= 0.001). The results of the Spearman’s correlation analysis showed triiodothyronine was positively correlated (r = 1.872, P<0.001), and cortisol and immunoglobulin E were negatively correlated ( r = -0.902 and -0.876, both P<0.001) with the prognosis of burn patients. Conclusion Triiodothyronine, cortisol and immunoglobulin E can all be used as biological indicators for the early evaluation of the severity and prognosis of burn patients in clinical practice. |
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