| 李静静,吕 璐,郭 艳,刘玉瑰,崔红英.湿润烧伤膏联合云南白药治疗宫颈上皮内瘤变术后创面疗效分析[J].中国烧伤创疡杂志,2024,(6):451~454. |
| DOI： |
| 中文关键词: 湿润烧伤膏 云南白药 宫颈上皮内瘤变 创面 炎症反应 |
| 英文关键词:MEBO Yunnan Baiyao Cervical intraepithelial neoplasia Wound Inflammatory reaction |
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| 中文摘要: |
| 【摘要】 目的 探讨湿润烧伤膏联合云南白药治疗宫颈上皮内瘤变 (CIN) 患者宫颈环形电切术后创面的效果。方法 选取2021年12月至2022年12月鹤壁市人民医院收治的拟行宫颈环形电切术治疗的90例CIN患者作为研究对象，并按照术后创面不同处理方法将其分为观察组 (45例)和对照组(45例)，观察组患者宫颈环形电切术后创面予以湿润烧伤膏与云南白药联合治疗，对照组患者宫颈环形电切术后创面不予处理，对比观察两组患者术后恢复情况、临床疗效、炎症因子水平与并发症发生情况。结果 观察组患者阴道出血时间、阴道排液时间和创面愈合时间均明显短于对照组 (t = 16.647、15.947、8.711，P 均<0.001);术后4周，观察组患者中显效19例、有效25例、无效1例，明显优于对照组患者的显效12例、有效 22 例、无效 11 例 (Z = -2.539，P =0.011); 术后 4 周，观察组患者血清白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α) 和 C 反应蛋白 (CRP) 水平均明显低于对照组 (t = 9.004、10.425、9.214，P均<0.001); 观察组患者术后并发症发生率为 4.44%，明显低于对照组患者的术后并发症发生率20.00% ( χ2 = 5.075，P = 0.024)。 结论 湿润烧伤膏与云南白药联合治疗CIN 患者宫颈环形电切术后创面，能够有效减轻炎症反应，缩短阴道出血及排液时间，加快创面愈合，降低术后并发症发生率，疗效显著。 |
| 英文摘要: |
| 【Abstract】 Objective To study the clinical efficacy of MEBO combined with Yunnan Baiyao in the treatment of postoperative wounds of patients after loop electrosurgical excision procedure for cervical intraepithelial neoplasia (CIN). Methods 90 patients with CIN, admitted to The People’s Hospital of Hebi from December 2021 to December 2022 for loop electrosurgical excision procedure, were enrolled as research subjects and divided into the study group (n = 45) and the control group (n = 45) according to the different managements they received for postoperative wounds. After the loop electrosurgical excision procedure, the postoperative wounds of patients were treated with MEBO combined with Yunnan Baiyao in the study group, whereas the postoperative wounds of patients were not treated in the control group. The recovery condition after surgery, clinical efficacy, inflammatory factor levels and the occurrence of complications were compared between the two groups. Results The vaginal bleeding time, vaginal drainage time and wound healing time of patients in the study group were significantly shorter than those in the control group ( t = 16.647, 15.947 and 8.711, all P<0.001). 4 weeks after surgery, 19 cases were markedly effective, 25 cases were effective, and 1 case was ineffective in the study group, which was much better than that in the control group (Z = - 2.539, P = 0.011) - 12 cases markedly effective, 22 cases effective, and 11 cases ineffective; the levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) of patients were all markedly lower in the study group compared with the control group (t = 9.004, 10.425 and 9.214, all P<0.001); the incidence of postoperative complications of patients was 4.44% in the study group, being significantly lower than the corresponding 20.00% in the control group ( χ2 = 5.075, P = 0.024). Conclusion MEBO combined with Yunnan Baiyao in the treatment of postoperative wounds of patients with CIN after loop electrosurgical excision procedure can effectively reduce inflammatory reactions, shorten the time of vaginal bleeding and drainage, accelerate wound healing and reduce the incidence of postoperative complications, and the clinical efficacy is definite. |
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