| 王 瑞,阮倩倩.学龄期儿童消化性溃疡并发出血的危险因素分析[J].中国烧伤创疡杂志,2024,(6):482~486. |
| DOI： |
| 中文关键词: |
| 英文关键词: |
| 基金项目: |
|
| 摘要点击次数: 305 |
| 全文下载次数: 712 |
| 中文摘要: |
| 【摘要】 目的 探讨分析学龄期儿童消化性溃疡并发出血的相关危险因素。 方法 选取 2020 年3月至2023年3月南阳市中心医院收治的213例学龄期消化性溃疡患儿作为研究对象, 收集患儿性别、有无家族史、年龄、溃疡类型、溃疡病程、是否喜好酸辣、有无幽门螺杆菌 (Hp) 感染、有无心理障碍、有无可加重消化性溃疡病情药物 (抗生素、激素、非甾体类抗炎药等) 应用史、临床症状 (有无呕血、柏油样便或血便等)、是否并发出血等相关资料，并根据患儿并发出血情况将其分为出血组和非出血组, Logistic 回归分析并发出血的相关危险因素。 结果 213 例消化性溃疡患儿并发出血 60 例 (28.17%), 临床表现为呕血 25 例 (41.67%)、柏油样便35 例 (58.33%)、嗳气反酸 22 例 (36.67%)、腹痛不适 20 例 (33.33%)、恶心呕吐 21 例 (35.00%), 设为出血组; 其余 153 例 (71.83%) 未并发出血, 设为非出血组。 单因素分析结果显示, 出血组中性别为男性、有家族史、年龄为 11~ 13 岁、溃疡病程≥1 年、喜好酸辣、有 Hp 感染、有心理障碍、有可加重消化性溃疡病情药物应用史的患儿明显多于非出血组 (χ2 = 7.502、50.233、8.851、6.927、7.148、8.759、4.719、7.392, P = 0.006?P<0.001、P= 0.003、P= 0.008、P= 0.008、P= 0.003、P= 0.030、P= 0.007)。 Logistic 回归分析结果显示, 性别为男性、有家族史、年龄为 11~ 13 岁、溃疡病程≥1 年、喜好酸辣、有 Hp 感染、有心理障碍、有可加重消化性溃疡病情药物应用史是学龄期儿童消化性溃疡并发出血的独立危险因素 ( 95% CI 为 1.329 ~ 4.516、1.318 ~11.888、1.848~ 32.710、1.188~ 6.046、1.133~ 5.763、1.937~ 7.914、1.182~ 11.257、1.155~ 1.771, P = 0.004、0.014、0.005、0.017、0.023、0.001、0.024、0.001)。 结论 学龄期儿童消化性溃疡并发出血以呕血和柏油样便为主要临床表现, 且其发生与性别、有无家族史、年龄、溃疡病程、是否喜好酸辣、有无 Hp 感染、有无心理障碍、有无可加重消化性溃疡病情药物应用史密切相关。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the risk factors for hemorrhage occurrence in school-age children with peptic ulcer. Methods 213 school-age children patients with peptic ulcer admitted to Nanyang Central Hospital from March 2020 to March 2023 were selected as research subjects, and their data were collected including sex, family history, age, type of ulcer, duration of ulcer, hot and sour taste preference, Helicobacter pylori (Hp) infection, psychological disorders, history of application of medications that may aggravate peptic ulcer (antibiotics, hormones, nonsteroidal anti-inflammatory drugs, etc.), clinical symptoms (hematemesis, tarry stool or bloody stool, etc.), and complication of hemorrhage. The children patients were divided into hemorrhage group and non-hemorrhage group based on the occurrence of hemorrhage. Logistic regression analysis was conducted to analyze the risk factors for the complication of hemorrhage. Results Among the 213 children patients with peptic ulcer, 60 patients ( 28.17%) were complicated with hemorrhage, being set up as the hemorrhage group and with clinical manifestations of hematemesis in 25 cases ( 41.67%), tarry stool in 35 cases (58.33%), belching and acid regurgitation in 22 cases ( 36.67%), abdominal pain and discomfort in 20 cases (33.33%), and nausea and vomiting in 21 cases (35.00%); and the other 153 cases (71.83%) without the occurrence of hemorrhage were set as non-hemorrhage group.The results of univariate analysis showed that the proportions of children patients with male gender, family history, age of 11-13 years, ulcer duration≥1 year, hot and sour taste preference, Hp infection, psychological disorders, and history of application of medications that may aggravate peptic ulcer were significantly higher in the hemorrhage group compared with the non-hemorrhage group ( χ2 = 7.502, 50.233, 8.851, 6.927, 7.148, 8.759, 4.719 and 7.392, P= 0.006, P<0.001, P= 0.003, P = 0.008, P = 0.008, P = 0.003, P = 0.030, P = 0.007).Multivariate Logistic regression analysis showed that, gender of male, family history, age of 11-13 years, ulcer duration≥ 1 year, hot and sour taste preference, Hp infection, psychological disorders, and history of application of medications that may aggravate peptic ulcer were independent risk factors for the occurrence of hemorrhage in school-age children with peptic ulcer (95%CI: 1.329-4.516, 1.318-11.888, 1.848-32.710, 1.188-6.046, 1.133-5.763, 1.937-7.914, 1.182-11.257, 1.155-1.771, P = 0.004, 0.014, 0.005, 0.017, 0.023, 0.001, 0.024 and 0.001) . Conclusion The main clinical manifestations of peptic ulcer complicated with hemorrhage in school-age children are hematemesis and tarry stool. The occurrence of hemorrhage is closely related to patients’ gender, family history, age, duration of ulcer, hot and sour taste preference, Hp infection, psychological disorders, and history of application of medications that may aggravate peptic ulcer. |
|
|
|
|
