• 连续性血液净化联合异甘草酸镁治疗烧伤脓毒症效果分析
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    中文关键词:  连续性血液净化  异甘草酸镁  烧伤  脓毒症  炎症反应  免疫功能  疾病严重程度
    英文关键词:【 Keywords 】 Continuous blood purification  Palindronate  burn  Sepsis  Inflammatory response  immunity  Severity of illness
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    作者单位邮编
    林美霞 刘畅* 商丘市第一人民医院血液净化室 河南商丘 476100 476100
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    中文摘要:
          目的 分析连续性血液净化联合异甘草酸镁治疗烧伤脓毒症的效果。方法 选取2020年6月至2024年6月收治的40例烧伤脓毒症患者为研究对象,进行连续性血液净化联合异甘草酸镁治疗,观察中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、白细胞介素-6(Interleukin-6,IL-6)、降钙素原、C反应蛋白(C-reactive protein,CRP)等炎症反应指标,免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白A(immunoglobulin A,IgA)等免疫功能指标、疾病严重程度(SOFA评分)。结果 治疗第24、48、72小时时,NLR、白细胞介素-6、降钙素原、C反应蛋白水平明显低于治疗前(P<0.05),IgG、IgM、IgA水平高于治疗前(P<0.05),SOFA评分低于治疗前(P<0.05)。结论 连续性血液净化联合异甘草酸镁治疗烧伤脓毒症,有利于降低患者炎症反应程度,提高患者免疫功能,改善病情严重程度。
    英文摘要:
          Objective: To analyze the efficacy of continuous blood purification combined with palindromic acid in the treatment of burn sepsis. Method: Forty patients with burn sepsis admitted from June 2020 to June 2024 were selected as the study subjects and treated with continuous blood purification combined with polidocanol. Inflammatory response indicators such as neutrophil to lymphocyte ratio (NLR), interleukin-6 (IL-6), procalcitonin, C-reactive protein (CRP), and immune functions such as immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA) were observed. Indicator, severity of disease (SOFA score). At 24, 48, and 72 hours of treatment, the levels of NLR, interleukin-6, procalcitonin, and C-reactive protein were significantly lower than before treatment (P<0.05), while the levels of IgG, IgM, and IgA were higher than before treatment (P<0.05), and the SOFA score was lower than before treatment (P<0.05). Conclusion: The combination of continuous blood purification and polidocanol in the treatment of burn sepsis is beneficial in reducing the degree of inflammatory response, improving the patient's immune function, and alleviating the severity of the condition.