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| DOI： |
| 中文关键词: [关键词]Cr、KIM-1、NGAL 重度烧伤 急性肾损伤 |
| 英文关键词:[Key words]Cr, KIM-1, NGAL Severe burns Acute kidney injury |
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| 摘要点击次数: 43 |
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| 中文摘要: |
| [摘要] 目的：分析Cr、KIM-1、NGAL联合预测重度烧伤患者早期急性肾损伤的价值。方法：选取2021年1月-2025年1月期间在我院接受治疗的重度烧伤患者120例作为研究对象，收集患者入院后12、24、48小时Cr、KIM-1、NGAL水平等资料，分析Cr、KIM-1、NGAL联合预测重度烧伤患者早期急性肾损伤的价值。结果：120例患者中最终确诊为AKI的患者有45例（37.5%），定义为AKI组；余75例患者定义为非AKI组。AKI组患者肌酐水平在烧伤后12小时内两组差异无统计学意义（P>0.05），但在24小时和48小时后AKI组显著高于非AKI组（P<0.05），KIM - 1和NGAL水平在烧伤后12小时、24小时和48小时均显著高于非AKI组（P<0.05）。代入24小时Cr、KIM-1、NGAL值进行Logistic回归分析，结果显示，入院24小时Cr、KIM-1、NGAL是重度烧伤患者早期发生急性肾损伤的独立影响因素（P<0.05）。ROC曲线分析结果显示，肌酐、KIM-1和NGAL联合检测的曲线下面积以及敏感度、特异度显著高于单一指标检测，表明联合检测能够显著提高早期AKI的诊断准确性。结论：肌酐、KIM-1和NGAL联合预测重度烧伤患者早期急性肾损伤具有较高的临床价值，能够显著提高预测的准确性、及时性和全面性，有助于优化治疗决策，改善患者预后，为临床提供更有效的预测工具。 |
| 英文摘要: |
| [Abstract] Objective: To analyze the value of Cr, KIM-1 and NGAL combined in predicting early acute kidney injury in severe burn patients. Methods: 120 patients with severe burn who received treatment in our hospital from January 2021 to January 2025 were selected as the study objects. Data on the levels of Cr, KIM-1 and NGAL were collected 12, 24 and 48 hours after admission to analyze the value of Cr, KIM-1 and NGAL combined in predicting early acute kidney injury in patients with severe burn. Results: Among the 120 patients, 45 cases (37.5%) were diagnosed with AKI, which was defined as AKI group. The remaining 75 patients were classified as non-AKI group. There was no significant difference in creatinine level between the two groups within 12 h after burn in AKI group (P>0.05), but the level of creatinine in AKI group was significantly higher than that in non-AKI group after 24 h and 48 h (P<0.05). KIM-1 and NGAL levels were significantly higher than those in non-AKI group at 12 h, 24 h and 48 h after burn (P<0.05). Logistic regression analysis was performed with 24-hour Cr, KIM-1 and NGAL values, and the results showed that 24-hour Cr, KIM-1 and NGAL were independent influencing factors for early acute kidney injury in severe burn patients (P<0.05). ROC curve analysis results showed that the area under the curve, sensitivity and specificity of the combined detection of creatinine, KIM-1 and NGAL were significantly higher than that of single index detection, indicating that the combined detection could significantly improve the diagnostic accuracy of early AKI. Conclusion: The combination of creatinine, KIM-1 and NGAL has high clinical value in predicting early acute kidney injury in severe burn patients, which can significantly improve the accuracy, timeliness and comprehensiveness of prediction, help optimize treatment decision, improve patient prognosis, and provide a more effective prediction tool for clinical practice. |
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